TWEAK Antibody (CARL-1): sc-56248

TWEAK Antibody (CARL-1) is a mouse monoclonal IgG3 kappa light chain antibody that detects the TWEAK protein of human origin by flow cytometry (FCM). Anti-TWEAK antibody (CARL-1) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. TWEAK, also known as Apo-3L, is a member of the tumor necrosis factor (TNF) superfamily, which plays a crucial role in mediating inflammation and regulating immune responses. TWEAK is primarily located on the cell surface as a type II transmembrane protein, where proteolytic processing releases a soluble homotrimeric form. TWEAK′s existence in both membrane-bound and soluble forms enables versatile signaling mechanisms that influence various cellular processes, including apoptosis and cell differentiation. Understanding TWEAK′s localization and processing helps elucidate its role in immune regulation and potential implications in inflammatory diseases.

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TWEAK Antibody (CARL-1) References:

1. TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages.  |  Kaplan, MJ., et al. 2000. J Immunol. 164: 2897-904. PMID: 10706675
2. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine.  |  Dogra, C., et al. 2007. FASEB J. 21: 1857-69. PMID: 17314137
3. TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy.  |  Gupta, RK., et al. 2021. Sci Immunol. 6: eabi8823. PMID: 34797693
4. Analysis of TNF-like weak inducer of apoptosis for detecting lupus nephritis.  |  Susianti, H., et al. 2022. Comp Clin Path. 31: 313-316. PMID: 35250424
5. Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis.  |  Liu, X., et al. 2024. Cancer Res. 84: 1352-1371. PMID: 38335276
6. A family of ligands for the TNF receptor superfamily.  |  Cosman, D. 1994. Stem Cells. 12: 440-55. PMID: 7528588
7. Contenders in FasL/TNF death signaling.  |  Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
8. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
9. Transducers of life and death: TNF receptor superfamily and associated proteins.  |  Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378
10. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.  |  Pitti, RM., et al. 1996. J Biol Chem. 271: 12687-90. PMID: 8663110
11. Identification and characterization of a new member of the TNF family that induces apoptosis.  |  Wiley, SR., et al. 1995. Immunity. 3: 673-82. PMID: 8777713
12. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.  |  Chicheportiche, Y., et al. 1997. J Biol Chem. 272: 32401-10. PMID: 9405449

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TWEAK Antibody (CARL-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TWEAK Antibody (CARL-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TWEAK Antibody (CARL-1) Specifications

Alternate Product Name: TWEAK

Product Clone Name: CARL-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids:

Epitope Target: TWEAK

Epitope Species: human

Product Reactivity/Detection: TWEAK

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TWEAK Antibody (CARL-1): FITC: Fluoroscein, PE: Phycoerythrin

The preferred TWEAK antibody is TWEAK Antibody (MTW-1): sc-56251.