tuberin Antibody (E-9): sc-365103
- tuberin Antibody (E-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of tuberin of human origin
- recommended for detection of tuberin of mouse, rat and human origin by WB, IP, IF and ELISA
- See tuberin (B-5): sc-271314 for tuberin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for tuberin Antibody (E-9) for WB applications. These reagents are now offered in bundles with tuberin Antibody (E-9) (see ordering information below).
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SEE ALSO...
Tuberin Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects tuberin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tuberin, a protein consisting of 1784 amino acids, plays a crucial role in the regulation of cell growth and proliferation, making tuberin vital for maintaining cellular homeostasis. Tuberin is primarily localized in membrane fractions, where tuberin interacts with various signaling pathways, including the Ras signaling cascade, to modulate the intrinsic GTPase activity of Rap1A. This interaction is significant because tuberin helps control cellular responses to growth factors and stress, thereby influencing tumorigenesis and other cellular processes. Mutations in the TSC2 gene, which encodes tuberin, are associated with tuberous sclerosis, a genetic disorder characterized by the formation of benign tumors and neurological issues. The TSC2 gene is located on human chromosome 16, and TSC2′s mouse homolog is found on chromosome 17, highlighting the evolutionary conservation of tuberin. Anti-tuberin antibody (E-9) is an essential tool for researchers studying the molecular mechanisms underlying tuberous sclerosis and related pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
tuberin Antibody (E-9) | sc-365103 | 200 µg/ml | $322.00 | |||
tuberin Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-540312 | 200 µg Ab; 10 µg BP | $361.00 | |||
tuberin Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-542033 | 200 µg Ab; 20 µg BP | $361.00 | |||
tuberin (E-9) Neutralizing Peptide | sc-365103 P | 100 µg/0.5 ml | $69.00 |