TSPY Antibody (SF-7): sc-69844

TSPY Antibody (SF-7) is a mouse monoclonal IgG1 antibody that detects testis-specific protein Y-encoded (TSPY) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TSPY is a crucial protein located on the human proximal Yp gene, originating from a tandem gene cluster that has been conserved across mammalian species for over 80 million years, highlighting its evolutionary significance. TSPY plays a vital role in cell cycle progression, cell proliferation, and tumorigenesis, making TSPY an important factor in various cancers, including gonadoblastoma, testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. TSPY expression is influenced by the Sox family of proteins, and TSPY activity is dependent on phosphorylation, which is essential for its function in oncogenesis. Given TSPY′s involvement in tumor development, anti-TSPY antibody (SF-7) is being explored as a potential candidate for immunotherapy strategies, particularly in hepatocellular carcinoma, where TSPY may contribute to vaccine development aimed at enhancing patient outcomes. TSPY (SF-7) antibody serves as an invaluable tool for researchers investigating TSPY′s role in cancer biology and therapeutic applications.

The preferred TSPY antibody is TSPY Antibody (H-11): sc-137050.