TSPY Activators
TSPY activators are a collection of molecules that are not direct activators of TSPY but have the capacity to modulate the cellular and signaling environment in which TSPY functions. These compounds act upon various biological pathways, including those involved in spermatogenesis, cell proliferation, hormonal signaling, and testicular development.
For instance, retinoic acid and fenretinide interact with retinoic acid receptors, influencing gene expression patterns critical for testicular cell differentiation, thereby potentially altering TSPY expression levels. Testolactone, by inhibiting aromatase, can elevate testosterone levels, which may exert a regulatory effect on genes within the Y chromosome, including TSPY. Compounds like dibutyryl cyclic AMP and rolipram that elevate intracellular cAMP levels and subsequently activate PKA can indirectly influence transcription factors that govern the expression of genes pertinent to testicular function. On the other hand, elements like zinc sulfate are critical for the maintenance of reproductive organ functionality and hormone production, possibly impacting TSPY regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A that regulates gene expression through retinoic acid receptors, which can influence spermatogenesis and may impact the expression of TSPY by modulating the differentiation of spermatogenic cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that activates protein kinase A (PKA), potentially influencing the phosphorylation status of transcription factors involved in the regulation of genes like TSPY related to testicular function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A phosphodiesterase inhibitor that increases cAMP by preventing its degradation, potentially leading to activation of PKA and subsequent effects on gene expression, including genes involved in spermatogenesis like TSPY. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
A synthetic retinoid that affects cell proliferation and differentiation; it may alter the retinoic acid signaling pathways that can impact TSPY expression indirectly through effects on testicular cell development. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
An essential mineral that plays a crucial role in hormone production, and it may contribute to the regulation of genes involved in testicular development and function, which could include TSPY. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Enhances calcium and phosphate homeostasis, and also influences hormone production in the testes, which may affect the expression of TSPY by altering the testicular hormonal milieu. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
An endocrine disruptor that can mimic estrogen and may affect hormonal signaling pathways, potentially causing dysregulation of genes involved in reproductive tissues, including those associated with TSPY expression. | ||||||
Clomiphene Citrate | 50-41-9 | sc-205636 sc-205636A | 1 g 5 g | $84.00 $176.00 | 1 | |
A selective estrogen receptor modulator that can lead to increased gonadotropin release and subsequently influence testicular function, which could have downstream effects on TSPY expression. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
A flavonoid with antioxidant properties that can affect signaling pathways related to cell growth and differentiation, potentially influencing the cellular environment in which TSPY operates. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
A synthetic estrogen that alters hormonal signaling and could influence the expression of genes related to testicular development and function, potentially including TSPY. | ||||||