TSHR Antibody (A9): sc-57491

TSHR Antibody (A9) is a mouse monoclonal IgG1 antibody that detects thyroid-stimulating hormone receptor (TSHR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TSHR is a critical glycoprotein located on the surface of thyroid follicular cells, where TSHR plays a vital role in regulating thyroid hormone synthesis and secretion. Anti-TSHR antibody (A9) recognizes a receptor whose activation by thyroid-stimulating hormone (TSH) initiates a cascade of intracellular signaling pathways that ultimately lead to the production of thyroid hormones, which are essential for maintaining metabolic homeostasis and overall physiological balance. TSHR is also implicated in various thyroid disorders, including Graves′ disease, where autoantibodies can aberrantly activate TSHR, leading to hyperthyroidism. The structural integrity of TSHR, particularly the third cytoplasmic loop, is crucial for function, as TSHR is involved in the regulation of inositol phosphate and cyclic adenosine monophosphate (cAMP) formation, highlighting TSHR′s importance in endocrine signaling. TSHR monoclonal antibody (A9) provides a valuable tool for researchers studying thyroid function and related pathologies, enabling the exploration of TSHR′s role in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

TSHR Antibody (A9) References:

1. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.  |  Szkudlinski, MW., et al. 2002. Physiol Rev. 82: 473-502. PMID: 11917095
2. Identification of Functional Thyroid Stimulating Hormone Receptor and TSHR Gene Mutations in Hepatocellular Carcinoma.  |  Shih, YL., et al. 2018. Anticancer Res. 38: 2793-2802. PMID: 29715101
3. Thyroid-Stimulating Hormone Receptor Expression on Primary Cultured Human Extraocular Muscle Myoblasts.  |  Choi, HY., et al. 2018. Curr Eye Res. 43: 1484-1488. PMID: 30009641
4. Analytical performance evaluation of thyroid-stimulating hormone receptor antibody (TRAb) immunoassays.  |  Higgins, V., et al. 2020. Clin Biochem. 86: 56-60. PMID: 32858059
5. Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity.  |  Bakhtyukov, AA., et al. 2022. Dokl Biochem Biophys. 503: 67-70. PMID: 35538280
6. Thyroid-Stimulating Antibody/Thyroid-Stimulating Hormone Receptor Antibody Ratio as a Sensitive Screening Test for Active Graves' Orbitopathy.  |  Nakano, M., et al. 2022. Endocr Pract. 28: 1050-1054. PMID: 35870804
7. Risk of malignancy in cytologically indeterminate thyroid nodules harboring thyroid stimulating hormone receptor mutations.  |  Whitmer, D., et al. 2022. Front Endocrinol (Lausanne). 13: 1073592. PMID: 36619548
8. Expression and Clinical Significance of Thyroid-stimulating hormone receptor in the Subtypes of Papillary thyroid carcinomas.  |  Shen, W., et al. 2023. Pak J Med Sci. 39: 198-202. PMID: 36694763
9. Thyroid hormone deprival and TSH/TSHR signaling deficiency lead to central hypothyroidism-associated intestinal dysplasia.  |  Peng, L., et al. 2024. Life Sci. 345: 122577. PMID: 38521387
10. Zirconium- 89 Labeled Antibody K1-70 for PET Imaging of Thyroid-stimulating Hormone Receptor Expression in Thyroid Cancer.  |  Parent, EE., et al. 2024. Mol Imaging Biol. 26: 847-857. PMID: 39174789

The preferred TSHR antibody is TSHR Antibody (3B12): sc-53542.