TrxR2 Antibody (D-12): sc-166259

TrxR2 Antibody (D-12) is a mouse monoclonal IgG2b antibody that detects Thioredoxin reductase 2 (TrxR2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TrxR2 is a vital redox protein localized in the mitochondria, where TrxR2 plays a crucial role in maintaining cellular health by scavenging reactive oxygen species (ROS) and regulating the mitochondrial apoptosis signaling pathway. This localization is significant because the mitochondria are the powerhouse of the cell, and mitochondrial dysfunction is often linked to various diseases, including neurodegenerative disorders and cancer. By controlling oxidative stress within the mitochondria, TrxR2 helps to prevent cellular damage and apoptosis, thereby contributing to cell viability. Furthermore, TrxR2 interacts with other proteins involved in redox regulation, enhancing TrxR2′s protective role against oxidative damage. TrxR2 inhibition has been explored as a potential therapeutic strategy for treating cancer and other diseases, highlighting TrxR2′s importance in both health and disease. Anti-TrxR2 antibody (D-12) is an essential tool for researchers studying the intricate mechanisms of redox biology and mitochondrial function.

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TrxR2 Antibody (D-12) References:

1. Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation.  |  Kim, MR., et al. 2003. Biochem Biophys Res Commun. 304: 119-24. PMID: 12705894
2. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.  |  Kipp, AP., et al. 2012. Biochim Biophys Acta. 1820: 1588-96. PMID: 22683372
3. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.  |  Yan, J., et al. 2016. Exp Cell Res. 344: 67-75. PMID: 27107686
4. p53R2 regulates thioredoxin reductase activity through interaction with TrxR2.  |  Park, SJ., et al. 2017. Biochem Biophys Res Commun. 482: 706-712. PMID: 27866984
5. Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.  |  Bu, L., et al. 2017. Life Sci. 178: 35-41. PMID: 28414076
6. TrxR2 overexpression alleviates inflammation-mediated neuronal death via reducing the oxidative stress and activating the Akt-Parkin pathway.  |  Gao, J., et al. 2019. Toxicol Res (Camb). 8: 641-653. PMID: 31588341
7. miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.  |  Bu, L., et al. 2021. Acta Biochim Biophys Sin (Shanghai). 53: 189-200. PMID: 33332541
8. The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity.  |  Kameritsch, P., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33579817
9. Synthesis of mitochondria-targeted menadione cation derivatives: Inhibiting mitochondrial thioredoxin reductase (TrxR2) and inducing apoptosis in MGC-803 cells.  |  Tang, Q., et al. 2022. Bioorg Med Chem Lett. 60: 128586. PMID: 35085721
10. Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function.  |  Chocron, ES., et al. 2022. Commun Biol. 5: 467. PMID: 35577894

The preferred TrxR2 antibody is TrxR2 Antibody (B-10): sc-365714.