TRP1 Antibody (F-7): sc-393942
- TRP1 Antibody (F-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 526-536 near the C-terminus of TRP1 of mouse origin
- recommended for detection of TRP1 of mouse and rat origin by WB, IP, IF and ELISA
- See TRP1 (G-9): sc-166857 for TRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TRP1 Antibody (F-7) for WB applications. This reagent is now offered in a bundle with TRP1 Antibody (F-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TRP1 Antibody (F-7) is a mouse monoclonal IgG2b antibody that detects TRP1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, functioning as a melanogenic enzyme that contributes to the production of eumelanin and pheomelanin, the two primary types of melanin found in vertebrates. TRP1 is predominantly located in the melanosomes of melanocytes, where TRP1 works in concert with tyrosinase and TRP2 to facilitate the conversion of tyrosine to melanin. Proper localization of TRP1 is essential for enzymatic activity, ensuring that substrate and necessary cofactors are available for melanin synthesis. TRP1 interacts with tyrosinase, stabilizing tyrosinase within the melanosomal membrane and enhancing activity, which underscores TRP1′s importance in maintaining the integrity and functionality of melanin production machinery. Deficiencies in TRP1 can lead to pigmentation disorders, highlighting TRP1′s significance in dermatology and genetic research. Anti-TRP1 antibody (F-7) is an invaluable tool for studying melanin synthesis dynamics and molecular mechanisms underlying pigmentation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRP1 Antibody (F-7) | sc-393942 | 200 µg/ml | $316.00 | |||
TRP1 Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-535931 | 200 µg Ab; 40 µg BP | $354.00 | |||
TRP1 (F-7) Neutralizing Peptide | sc-393942 P | 100 µg/0.5 ml | $68.00 |