Tropomyosin Antibody (C-3): sc-376339
- Tropomyosin Antibody (C-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 223-259 near the C-terminus of Tropomyosin β of human origin
- recommended for detection of Tropomyosin α isoforms 1-4, Tropomyosin β isoforms 1-3, Tropomyosin γ and Tropomyosin 4 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Tropomyosin Antibody (C-3) for WB and IHC(P) applications. These reagents are now offered in bundles with Tropomyosin Antibody (C-3) (see ordering information below).
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Tropomyosin Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects Tropomyosin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Tropomyosin plays a crucial role in muscle contraction and cellular structure by binding to actin filaments, thereby stabilizing their structure and regulating the interaction between actin and myosin. This interaction is vital for muscle function, as Tropomyosin allows for the precise control of muscle contraction and relaxation. Additionally, Tropomyosin is involved in various cellular processes beyond muscle tissue, including cell motility and shape maintenance in non-muscle cells. Tropomyosin is encoded by two genes, TPM1 and TPM2, which undergo alternative splicing to produce multiple isoforms, each with distinct roles in different tissues. The presence of Tropomyosin in virtually all eukaryotic cells underscores its importance in maintaining cellular integrity and function. Anti-Tropomyosin antibody (C-3) is an essential tool for researchers studying muscle biology, cytoskeletal dynamics, and related pathologies, providing reliable detection and characterization of this critical protein.
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Tropomyosin Antibody (C-3) References:
- The molecular basis for tropomyosin isoform diversity. | Lees-Miller, JP. and Helfman, DM. 1991. Bioessays. 13: 429-37. PMID: 1796905
- Gestalt-binding of tropomyosin to actin filaments. | Holmes, KC. and Lehman, W. 2008. J Muscle Res Cell Motil. 29: 213-9. PMID: 19116763
- Tropomyosin as a regulator of cancer cell transformation. | Helfman, DM., et al. 2008. Adv Exp Med Biol. 644: 124-31. PMID: 19209818
- Gestalt-binding of tropomyosin on actin during thin filament activation. | Lehman, W., et al. 2013. J Muscle Res Cell Motil. 34: 155-63. PMID: 23666668
- Phosphorylation of tropomyosin in striated muscle. | Heeley, DH. 2013. J Muscle Res Cell Motil. 34: 233-7. PMID: 23812782
- Expression of tropomyosin in relation to myofibrillogenesis in axolotl hearts. | Zajdel, RW., et al. 2013. Regen Med Res. 1: 8. PMID: 25984327
- Direct observation of tropomyosin binding to actin filaments. | Schmidt, WM., et al. 2015. Cytoskeleton (Hoboken). 72: 292-303. PMID: 26033920
- The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. | Lehman, W., et al. 2019. Biophys J. 116: 2275-2284. PMID: 31130236
- Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. | Pavadai, E., et al. 2020. Biophys J. 118: 325-336. PMID: 31864661
- Myosin and tropomyosin-troponin complementarily regulate thermal activation of muscles. | Ishii, S., et al. 2023. J Gen Physiol. 155: PMID: 37870863
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tropomyosin Antibody (C-3) | sc-376339 | 200 µg/ml | $316.00 | |||
Tropomyosin Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-540549 | 200 µg Ab; 10 µg BP | $354.00 | |||
Tropomyosin Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-542198 | 200 µg Ab; 20 µg BP | $354.00 | |||
Tropomyosin (C-3) Neutralizing Peptide | sc-376339 P | 100 µg/0.5 ml | $68.00 |