TRIP6 Antibody (B-10): sc-376304
- TRIP6 Antibody (B-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 8-94 mapping near the N-terminus of TRIP6 of mouse origin
- recommended for detection of TRIP6 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRIP6 Antibody (B-10). This work is in progress.
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TRIP6 Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects TRIP6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIP6 is a LIM domain-containing protein that plays a critical role in cellular signaling and cytoskeletal organization, particularly at focal adhesion sites where TRIP6 interacts with various signaling molecules. TRIP6 is essential for mediating the effects of tumor necrosis factor (TNF) and interleukin-1 (IL-1) signaling pathways, which are pivotal in inflammatory responses and cellular stress. TRIP6′s ability to interact with receptor-interacting protein 2 (RIP2) and other key proteins like TRAF2 enhances TRIP6′s role in activating the NF-kappaB pathway, a crucial regulator of immune responses and cell survival. TRIP6 localization at focal adhesions not only underscores TRIP6′s importance in maintaining cell adhesion and motility but also highlights TRIP6′s potential as a therapeutic target in diseases characterized by dysregulated signaling, such as cancer and chronic inflammation. With robust reactivity and versatility in various applications, anti-TRIP6 antibody (B-10) is an invaluable tool for researchers investigating the intricate roles of TRIP6 in cellular processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRIP6 Antibody (B-10) References:
- TRIP6 regulates p27 KIP1 to promote tumorigenesis. | Lin, VT., et al. 2013. Mol Cell Biol. 33: 1394-409. PMID: 23339869
- TRIP6 regulates neural stem cell maintenance in the postnatal mammalian subventricular zone. | Lai, YJ., et al. 2014. Dev Dyn. 243: 1130-42. PMID: 25044744
- Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. | Lv, K., et al. 2015. J Neurosci. 35: 2559-71. PMID: 25673849
- TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a. | Zhao, W., et al. 2017. Biochem Biophys Res Commun. 494: 594-601. PMID: 29080747
- TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer. | Zhu, L., et al. 2019. Biologics. 13: 101-110. PMID: 31354238
- TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin. | Zhao, X., et al. 2020. Cancer Cell Int. 20: 51. PMID: 32082081
- TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation. | Wei, F. and Hao, Y. 2020. Int Immunopharmacol. 82: 106366. PMID: 32151960
- TRIP6 accelerates the proliferation and invasion of cervical cancer by upregulating oncogenic YAP signaling. | Yang, F., et al. 2020. Exp Cell Res. 396: 112248. PMID: 32853630
- TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis. | Yang, Y., et al. 2022. J Inflamm (Lond). 19: 1. PMID: 34983535
- ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines. | Daniel, P., et al. 2023. Genes (Basel). 14: PMID: 36833223
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIP6 Antibody (B-10) | sc-376304 | 200 µg/ml | $322.00 |