TRIM9 Antibody (D-11): sc-515040

TRIM9 Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects TRIM9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIM9, also known as Tripartite motif-containing protein 9 or RNF91, is a 710 amino acid protein belonging to the tripartite motif (TRIM) family, which is characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, and a RING finger. TRIM9 plays a crucial role in regulating synaptic vesicle exocytosis by interacting with the amino-terminal t-SNARE domain of SNAP25, thereby controlling the availability of SNAP25 for the formation of the SNARE complex, which is essential for neurotransmitter release. This regulatory function is vital for proper neuronal communication and synaptic plasticity, highlighting TRIM9′s importance in both normal brain function and potential neurological disorders. Additionally, TRIM9 exists in three isoforms due to alternative splicing, which may contribute to diverse functional roles in different cellular contexts. Anti-TRIM9 antibody (D-11) serves as an invaluable tool for researchers studying the intricate mechanisms of synaptic transmission and the broader implications of TRIM proteins in cellular processes.

The preferred TRIM9 antibody is TRIM9 Antibody (G-4): sc-515007.