Date published: 2026-5-5

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Triethylenetetramine (CAS 112-24-3)

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Alternate Names:
DEH 24; EPH 925; Trientine
Application:
Triethylenetetramine is a selective Cu(II) chelator and crosslinker
CAS Number:
112-24-3
Purity:
≥60%
Molecular Weight:
146.23
Molecular Formula:
C6H18N4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triethylenetetramine is a compound that functions as a chelating agent in experimental applications. It acts by forming coordination complexes with metal ions, particularly copper, in a process known as chelation. Has the ability to bind to metal ions through multiple sites, effectively sequestering them and preventing their participation in various chemical reactions. In this way, triethylenetetramine can be used to remove metal ions from solutions or to inhibit metal-catalyzed reactions in experimental systems. Its mode of action involves the formation of stable, water-soluble complexes with metal ions, thereby altering reactivity of the system. Chelating properties make it a useful for studying metal ion-dependent processes in experimental, as it can effectively modulate the availability and activity of metal ions in a controlled manner.


Triethylenetetramine (CAS 112-24-3) References

  1. Triethylenetetramine pharmacology and its clinical applications.  |  Lu, J. 2010. Mol Cancer Ther. 9: 2458-67. PMID: 20660601
  2. Complex N-acetylation of triethylenetetramine.  |  Cerrada-Gimenez, M., et al. 2011. Drug Metab Dispos. 39: 2242-9. PMID: 21878558
  3. Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.  |  Hyvönen, MT., et al. 2013. Drug Metab Dispos. 41: 30-2. PMID: 23024204
  4. Triethylenetetramine prevents insulin aggregation and fragmentation during copper catalyzed oxidation.  |  Torosantucci, R., et al. 2013. Eur J Pharm Biopharm. 84: 464-71. PMID: 23403016
  5. Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.  |  Hyvönen, MT., et al. 2016. Biochem J. 473: 1433-41. PMID: 27001865
  6. Water-dispersible triethylenetetramine-functionalized graphene: Preparation, characterization and application as an amperometric glucose sensor.  |  Ren, Q., et al. 2016. Mater Sci Eng C Mater Biol Appl. 68: 308-316. PMID: 27524025
  7. Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell.  |  Wang, L., et al. 2017. Oxid Med Cell Longev. 2017: 3481710. PMID: 28280522
  8. Triethylenetetramine-Based Semiconducting Fe(III) Metallogel: Effective Catalyst for Aryl-S Coupling.  |  Dhibar, S., et al. 2020. ACS Omega. 5: 2680-2689. PMID: 32095691
  9. Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.  |  Pietrocola, F., et al. 2020. Autophagy. 16: 1534-1536. PMID: 32544364
  10. Removal of wastewater phenolic compounds with triethylenetetramine functionalized polystyrene resin.  |  Teng, Q., et al. 2020. Water Sci Technol. 82: 440-453. PMID: 32960790
  11. Calcined Co(II)-Triethylenetetramine, Co(II)- Polyaniline-Thiourea as the Cathode Catalyst of Proton Exchanged Membrane Fuel Cell.  |  Huang, WY., et al. 2020. Polymers (Basel). 12: PMID: 33371521
  12. Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine.  |  Carucci, C., et al. 2021. Int J Mol Sci. 22: PMID: 34299286
  13. Adsorption of Cr6+ ion using activated Pisum sativum peels-triethylenetetramine.  |  El-Nemr, MA., et al. 2022. Environ Sci Pollut Res Int. 29: 91036-91060. PMID: 35881295
  14. Triethylenetetramine (TETA).  |  , ., et al. 2023. Toxicol Ind Health. 39: 183-187. PMID: 36941775

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triethylenetetramine, 100 g

sc-251328
100 g
$31.00

Triethylenetetramine, 500 g

sc-251328A
500 g
$35.00

Triethylenetetramine, 1 kg

sc-251328B
1 kg
$73.00

Triethylenetetramine, 2 kg

sc-251328C
2 kg
$116.00

Triethylenetetramine, 18 kg

sc-251328D
18 kg
$640.00