TRIAD1 Antibody (C-3): sc-390670
- TRIAD1 Antibody (C-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 314-481 mapping near the C-terminus of TRIAD1 of human origin
- recommended for detection of TRIAD1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG1 BP-HRP is the preferred secondary detection reagent for TRIAD1 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with TRIAD1 Antibody (C-3) (see ordering information below).
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TRIAD1 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects TRIAD1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIAD1, also known as ARIH2 or ARI2, is a 493 amino acid protein characterized by one IBR-type zinc finger and two RING-type zinc fingers, placing TRIAD1 within the ariadne subfamily of RBR proteins. TRIAD1 is primarily localized in the nucleus, where TRIAD1 functions as an E3 ubiquitin-protein ligase, facilitating the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to target substrates, which is essential for regulating protein degradation and cellular homeostasis. TRIAD1 undergoes post-translational modifications, including DNA damage-dependent phosphorylation, likely mediated by ATM or ATR kinases, which underscores TRIAD1′s importance in cellular responses to stress and DNA repair mechanisms. The gene encoding TRIAD1 is located on human chromosome 3, a region that contains over 1,100 genes, including those associated with various cancers, highlighting TRIAD1′s potential implications in tumorigenesis and relevance in cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIAD1 Antibody (C-3) | sc-390670 | 200 µg/ml | $322.00 | |||
TRIAD1 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-542709 | 200 µg Ab; 20 µg BP | $361.00 |