Trehalase Antibody (D-2): sc-390034

Trehalase Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Trehalase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Trehalase (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Trehalase, also known as TREH, TREA, or alpha,alpha-trehalose glucohydrolase, is a 583 amino acid protein that belongs to the glycosyl hydrolase 37 family and is primarily localized to the cell membrane and lipid anchors. Trehalase is predominantly expressed in the kidney, liver, and small intestine, where Trehalase plays a crucial role in hydrolyzing trehalose, a disaccharide composed of two glucose molecules found mainly in insects, fungi, and plants, into glucose, which serves as a vital energy source for cellular metabolism. Deficiencies in Trehalase can lead to trehalose intolerance, resulting in gastrointestinal symptoms, and may also serve as a marker for renal tubular damage. Trehalase features an N-terminal signal peptide, five potential N-glycosylation sites, and a C-terminal hydrophobic region that facilitates glycosylphosphatidylinositol (GPI) attachment. Additionally, Trehalase exists in two alternatively spliced isoforms, and the gene encoding Trehalase is located on human chromosome 11q23.3.

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Trehalase Antibody (D-2) References:

1. Cloning, characterization and mapping of the mouse trehalase (Treh) gene.  |  Oesterreicher, TJ., et al. 2001. Gene. 270: 211-20. PMID: 11404018
2. Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.  |  Ruf, J., et al. 1990. J Biol Chem. 265: 15034-9. PMID: 1697585
3. Fate and effects of the trehalase inhibitor trehazolin in the migratory locust (Locusta migratoria).  |  Liebl, M., et al. 2010. J Insect Physiol. 56: 567-74. PMID: 19958774
4. Different functions of the insect soluble and membrane-bound trehalase genes in chitin biosynthesis revealed by RNA interference.  |  Chen, J., et al. 2010. PLoS One. 5: e10133. PMID: 20405036
5. A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition.  |  Forcella, M., et al. 2010. Glycobiology. 20: 1186-95. PMID: 20542873
6. Expression of active and inactive recombinant soluble trehalase using baculovirus-silkworm expression system and their glycan structures.  |  Ujita, M., et al. 2011. J Biosci Bioeng. 111: 22-5. PMID: 20870456
7. Long-term effects of the trehalase inhibitor trehazolin on trehalase activity in locust flight muscle.  |  Wegener, G., et al. 2010. J Exp Biol. 213: 3852-7. PMID: 21037064
8. Genetically altering the expression of neutral trehalase gene affects conidiospore thermotolerance of the entomopathogenic fungus Metarhizium acridum.  |  Leng, Y., et al. 2011. BMC Microbiol. 11: 32. PMID: 21310069
9. Inhibition of trehalose breakdown increases new carbon partitioning into cellulosic biomass in Nicotiana tabacum.  |  Best, M., et al. 2011. Carbohydr Res. 346: 595-601. PMID: 21333278
10. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage.  |  Sasai-Takedatsu, M., et al. 1996. Nephron. 73: 179-85. PMID: 8773341
11. Molecular cloning, sequencing and expression of cDNA encoding human trehalase.  |  Ishihara, R., et al. 1997. Gene. 202: 69-74. PMID: 9427547

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Trehalase Antibody (D-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Trehalase Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Trehalase Antibody (D-2) Specifications

Alternate Product Name: Trehalase

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 181-405

Epitope Target: Trehalase

Epitope Species: human

Product Reactivity/Detection: Trehalase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Trehalase Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin