TRAX Antibody (56): sc-136108

TRAX Antibody (56) is a mouse monoclonal IgG1 antibody that detects TRAX in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TRAX, also known as translin-associated factor X or TSNAX, is a crucial nuclear protein that plays a significant role in DNA repair and RNA processing by interacting with translin, a DNA-binding protein involved in chromosomal translocations. TRAX is predominantly expressed in the brain and testis, where TRAX contains an N-terminal bipartite nuclear localization signal (NLS) that facilitates transport into the nucleus, and a leucine zipper domain that is vital for protein-protein interactions. The interaction between TRAX and translin enables the complex to engage with the protein kinase activator C1D, which is essential for the repair of DNA double-stranded breaks and the processing of dendritic RNA. Furthermore, TRAX acts as a transcriptional regulator of GAP-43, a growth-associated protein that is critical for axonal regeneration and cell proliferation, highlighting TRAX′s importance in neuronal development and repair mechanisms. With an ability to provide insights into these vital cellular processes, anti-TRAX antibody (56) is an invaluable tool for researchers studying the molecular underpinnings of neurobiology and genetic stability.

The preferred TRAX antibody is TRAX Antibody (B-10): sc-271402.