TRAPPC10 Antibody (RR-18): sc-101259

TRAPPC10 Antibody (RR-18) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRAPPC10 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TRAPPC10 antibody (RR-18) is available as a non-conjugated format. TRAPPC10, also known as TMEM1 (transmembrane protein 1), EHOC1 (epilepsy holoprosencephaly candidate 1 protein), or GT334, is a highly conserved 1,259 amino acid protein that plays a crucial role in vesicular transport within cells. TRAPPC10 is localized to the cis-Golgi apparatus, where TRAPPC10 is integral to the transport process from the endoplasmic reticulum to the Golgi apparatus, functioning as a key component of the multisubunit transport protein particle (TRAPP) complex. This localization maintains cellular homeostasis and ensures proper trafficking of proteins and lipids, which is essential for various cellular functions. Mutations in the gene encoding TRAPPC10 have been implicated in autoimmune polyglandular disease type 1 and Unverricht-Lundborg disease, an autosomal recessive form of progressive myoclonic epilepsy, highlighting TRAPPC10′s importance in both normal physiology and disease states.

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TRAPPC10 Antibody (RR-18) References:

1. Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes.  |  Deutsch, S., et al. 2005. Hum Mol Genet. 14: 3741-9. PMID: 16251198
2. Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex.  |  Cox, R., et al. 2007. BMC Evol Biol. 7: 12. PMID: 17274825
3. Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3.  |  Yamakawa, K., et al. 1995. Hum Mol Genet. 4: 709-16. PMID: 7633421
4. Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3.  |  Lalioti, MD., et al. 1996. Genomics. 35: 321-7. PMID: 8661145
5. Localization of 16 exons to a 450-kb region involved in the autoimmune polyglandular disease type I (APECED) on human chromosome 21q22.3.  |  Kudoh, J., et al. 1997. DNA Res. 4: 45-52. PMID: 9179495
6. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3.  |  Nagamine, K., et al. 1997. Biochem Biophys Res Commun. 235: 185-90. PMID: 9196060
7. Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21.  |  Nagamine, K., et al. 1997. Genomics. 42: 528-31. PMID: 9205129
8. Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3.  |  Lafrenière, RG., et al. 1997. Gene. 198: 313-21. PMID: 9370297

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRAPPC10 Antibody (RR-18) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TRAPPC10 Antibody (RR-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRAPPC10 Antibody (RR-18) Specifications

Alternate Product Name: TRAPPC10

Product Clone Name: RR-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1162-1258

Epitope Target: TMEM1

Epitope Species: human

Product Reactivity/Detection: TRAPPC10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TRAPPC10 Antibody (RR-18): N/A