transgelin-3 Antibody (438.1): sc-100960

transgelin-3 Antibody (438.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects transgelin-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-transgelin-3 antibody (438.1) is available as a non-conjugated format. Transgelin-3, also known as TAGLN2, NP22, or NP25, is predominantly expressed in the brain, distinguishing itself from homologs, transgelin and transgelin-2, which are primarily found in smooth muscle cells. Transgelin-3 features a putative actin-binding domain, two EF-hand motifs, and a calponin-homology domain, which are crucial for interactions with the cytoskeleton. These structural elements suggest transgelin-3 may play a significant role in neuronal plasticity, potentially influencing synaptic function and signaling pathways in the brain. Notably, transgelin-3 expression is upregulated in regions of the human brain affected by alcohol use, indicating involvement in neuroadaptive processes. Transgelin-3′s ability to colocalize with actin and tubulin further emphasizes importance in maintaining cellular architecture and facilitating dynamic changes in neuronal structure.

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transgelin-3 Antibody (438.1) References:

1. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain.  |  Fan, L., et al. 2001. J Neurochem. 76: 1275-81. PMID: 11238712
2. Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain.  |  Depaz, I., et al. 2003. Alcohol Clin Exp Res. 27: 1481-8. PMID: 14506410
3. Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain.  |  Depaz, IM., et al. 2005. J Neurosci Res. 81: 253-60. PMID: 15948156
4. The novel cytoskeleton-associated protein Neuronal protein 22: elevated expression in the developing rat brain.  |  Depaz, IM. and Wilce, PA. 2006. Brain Res. 1081: 59-64. PMID: 16542643
5. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations.  |  Ren, WZ., et al. 1994. Brain Res Mol Brain Res. 22: 173-85. PMID: 8015377

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-transgelin-3 Antibody (438.1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-transgelin-3 Antibody (438.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

transgelin-3 Antibody (438.1) Specifications

Alternate Product Name: transgelin-3

Product Clone Name: 438.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-200

Epitope Target: transgelin-3

Epitope Species: human

Product Reactivity/Detection: transgelin-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for transgelin-3 Antibody (438.1): N/A