transgelin-2 Antibody (D-8): sc-515586

transgelin-2 Antibody (D-8) is a mouse monoclonal IgG3 antibody that detects transgelin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Transgelin-2, also known as SM22α homolog, is a crucial protein expressed predominantly in smooth muscle cells and peritoneal B-1 cells, playing a significant role in the regulation of actin dynamics. The human transgelin-2 gene, designated TAGLN2, is located on chromosome 1q23.1-q25 and encodes a 199 amino acid protein that features a calponin-like repeat and a calponin-homology domain, which are essential for its interaction with actin. This interaction is vital as transgelin-2 binds to actin filaments, promoting the formation of gel-like structures that are critical for maintaining cellular integrity and facilitating smooth muscle contraction. Notably, during embryogenesis, transgelin-2 is expressed in various muscle types, but transgelin-2 expression becomes restricted to vascular and visceral smooth muscle cells in adulthood, with diminished levels in cardiac tissue. The downregulation of transgelin-2 in transformed cell lines suggests that transgelin-2 may serve as an early biomarker for cellular transformation, highlighting transgelin-2′s importance in both normal physiology and disease states. Anti-transgelin-2 antibody (D-8) is an invaluable tool for researchers investigating transgelin-2′s roles in smooth muscle function and its implications in various pathologies.

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transgelin-2 Antibody (D-8) References:

1. Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism.  |  Xiao, Y., et al. 2012. PLoS One. 7: e46510. PMID: 23056327
2. Functional significance of transgelin-2 in uterine cervical squamous cell carcinoma.  |  Yakabe, K., et al. 2016. J Obstet Gynaecol Res. 42: 566-72. PMID: 26891454
3. Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates.  |  Na, BR., et al. 2016. PLoS One. 11: e0156429. PMID: 27232882
4. Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas.  |  Beyer, SJ., et al. 2018. Oncotarget. 9: 37097-37111. PMID: 30647847
5. Transgelin 2 is required for embryo implantation by promoting actin polymerization.  |  Liang, X., et al. 2019. FASEB J. 33: 5667-5675. PMID: 30702937
6. Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration.  |  Zhou, Q., et al. 2019. Mol Med Rep. 19: 4919-4926. PMID: 30942422
7. Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2.  |  Shi, J., et al. 2020. Biochem Biophys Res Commun. 523: 632-638. PMID: 31941608
8. Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.  |  Ding, R., et al. 2022. J Physiol Biochem. 78: 99-108. PMID: 34553339
9. The Effects of a Transgelin-2 Agonist Administered at Different Times in a Mouse Model of Airway Hyperresponsiveness.  |  Yuan, HK., et al. 2022. Front Pharmacol. 13: 873612. PMID: 35784706
10. Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer.  |  Jo, JH., et al. 2024. BMC Cancer. 24: 357. PMID: 38509504

The preferred transgelin-2 antibody is transgelin-2 Antibody (C-12): sc-373928.