transferrin Antibody (D-9): sc-365871

Transferrin Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects transferrin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-transferrin antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Transferrin plays a crucial role in iron metabolism, serving as the primary transport protein for iron in the bloodstream. Transferrin binds iron ions with high affinity, facilitating their transport to various tissues, including the bone marrow, where iron is essential for hemoglobin synthesis in erythrocytes. Transferrin′s structure features two homologous lobes, each containing a specific iron-binding site, which is vital for function in iron homeostasis. Iron release in response to cellular needs prevents iron overload, which can lead to cellular damage and various diseases. Transferrin synthesis occurs predominantly in the liver, with lower levels produced in the testis and brain, highlighting transferrin′s importance in both systemic and localized iron regulation. Deficiencies or mutations in transferrin can lead to atransferrinemia, a rare genetic disorder characterized by microcytic anemia and iron overload, underscoring transferrin′s essential role in maintaining iron balance in the body.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

transferrin Antibody (D-9) References:

1. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line.  |  de Arriba Zerpa, GA., et al. 2000. J Neurosci Res. 61: 388-95. PMID: 10931525
2. Molecular characterization of a case of atransferrinemia.  |  Beutler, E., et al. 2000. Blood. 96: 4071-4. PMID: 11110675
3. Serum iron, transferrin saturation, ferritin, and dietary data in age-related macular degeneration.  |  Richer, S., et al. 2002. Am J Ther. 9: 25-8. PMID: 11782816
4. Regulation of transferrin gene expression.  |  Zakin, MM. 1992. FASEB J. 6: 3253-8. PMID: 1426763
5. [Expression and extracellular release of transferrin receptors on erythropoiesis].  |  Kohgo, Y., et al. 1991. Rinsho Ketsueki. 32: 580-6. PMID: 1890732
6. Transferrin glycosylation in hypoxia.  |  Regoeczi, E., et al. 1991. Biochem Cell Biol. 69: 239-44. PMID: 2054155
7. Transferrin-dependent lipid peroxidation.  |  Saito, M., et al. 1986. J Free Radic Biol Med. 2: 99-105. PMID: 3029212
8. Iron uptake and metabolism by hepatocytes.  |  Morgan, EH. and Baker, E. 1986. Fed Proc. 45: 2810-6. PMID: 3533647
9. Transferrin-mediated cellular iron uptake.  |  Irie, S. and Tavassoli, M. 1987. Am J Med Sci. 293: 103-11. PMID: 3551609
10. Human transferrin: cDNA characterization and chromosomal localization.  |  Yang, F., et al. 1984. Proc Natl Acad Sci U S A. 81: 2752-6. PMID: 6585826
11. The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure.  |  MacGillivray, RT., et al. 1983. J Biol Chem. 258: 3543-53. PMID: 6833213
12. Structure and function of transferrin.  |  Aisen, P. and Brown, EB. 1975. Prog Hematol. 9: 25-56. PMID: 766075

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-transferrin Antibody (D-9) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-transferrin Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

transferrin Antibody (D-9) Specifications

Alternate Product Name: TF (transferrin)

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 326-390

Epitope Target: transferrin

Epitope Species: human

Product Reactivity/Detection: transferrin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for transferrin Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin