TRα2 Antibody (1330): sc-56875
- TRα2 Antibody (1330) is a mouse monoclonal IgG1 provided at 100 µl
- raised against an N-terminal region of TRα2 of human origin
- recommended for detection of TRα2 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TRα2 Antibody (1330). This work is in progress.
QUICK LINKS
TRα2 Antibody (1330) is a mouse monoclonal IgG1 antibody that detects TRα2 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. TRα2, a C-terminal variant of the TRα1 isoform, plays a crucial role in thyroid hormone signaling by acting as a dominant negative antagonist, which means TRα2 can inhibit the effects of thyroid hormones on gene expression. This is particularly important because thyroid hormones are essential regulators of metabolism, growth, and development, and TRα2 can modulate the physiological responses to these hormones. Unlike TRα1, which can bind thyroid hormones and is involved in transcriptional activation, TRα2 does not bind thyroid hormones effectively and instead can interfere with the normal function of TRα1, thereby influencing various metabolic processes. The ability of TRα2 to localize in the nucleus and potentially in the cytoplasm underscores TRα2′s significance in cellular signaling pathways, making anti-TRα2 antibody (1330) an invaluable tool for researchers studying thyroid hormone action and its implications in metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRα2 Antibody (1330) References:
- Organ specific expression of thyroid hormone receptor mRNA and protein in different human tissues. | Shahrara, S., et al. 1999. Biol Pharm Bull. 22: 1027-33. PMID: 10549850
- Elevated expression of thyroid hormone receptor alpha 2 (c-erb A- alpha 2) in nasopharyngeal carcinoma. | Lee, JW., et al. 2000. Br J Cancer. 83: 1674-80. PMID: 11104565
- Thyroid hormone receptor (TR)alpha and TRbeta expression in breast cancer. | Ditsch, N., et al. 2013. Histol Histopathol. 28: 227-37. PMID: 23275305
- Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins. | Moran, C., et al. 2017. Thyroid. 27: 973-982. PMID: 28471274
- Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. | van Gucht, ALM., et al. 2017. Curr Top Dev Biol. 125: 337-355. PMID: 28527577
- Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Phosphorylation. | Liu, YY. and Brent, GA. 2018. Methods Mol Biol. 1801: 39-46. PMID: 29892815
- Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi. | Di Cicco, E., et al. 2021. Thyroid. 31: 1114-1126. PMID: 33509032
- Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality. | Sandsveden, M., et al. 2021. Breast Cancer Res. 23: 117. PMID: 34930399
- TRα2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action? | Hönes, GS., et al. 2022. Int J Mol Sci. 23: PMID: 35806002
- Cytoplasmic Localization of Thyroid Hormone Receptor (TR) Alpha and Nuclear Expression of Its Isoform TRα2 Determine Survival in Breast Cancer in Opposite Ways. | Schneider, M., et al. 2023. Cancers (Basel). 15: PMID: 37509273
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRα2 Antibody (1330) | sc-56875 | 100 µl | $322.00 |