TRα1/β1 Antibody (C3): sc-32754
- TRα1/β1 Antibody (C3) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against the ligand binding domain of TRβ1 of human origin
- recommended for detection of TRα1 and TRβ1 of human origin by WB and IP
- TransCruz reagent for Gel Supershift and ChIP applications (sc-32754 X, 200 µg/0.1 ml)
- See TRβ1 (J51): sc-737 for TRα1/β1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRα1/β1 Antibody (C3) for WB applications. These reagents are now offered in bundles with TRα1/β1 Antibody (C3) (see ordering information below).
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TRα1/β1 Antibody (C3) is a mouse monoclonal IgG1 antibody that detects TRα1/β1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. TRα1/β1 plays a crucial role in the regulation of metabolic and developmental processes as a ligand-dependent transcription factor, with TRα1/β1 activity significantly influenced by thyroid hormones such as 3,5,3′-triiodo-L-thyronine (T3). TRα1 is unique in localizing to both the nucleus and cytoplasm, and TRα1 remains the only thyroid hormone receptor imported into the mitochondrial matrix, highlighting TRα1′s importance in cellular metabolism and energy regulation. This localization allows TRα1 to participate in diverse signaling pathways, including those governing mitochondrial function and energy homeostasis. Additionally, TRβ1 interacts with the p85α subunit of PI 3-kinase, which is essential for T3-induced activation of Akt in pancreatic β cells, further emphasizing TRα1/β1′s significance in metabolic regulation. Anti-TRα1/β1 antibody (C3) serves as an invaluable tool for researchers studying the intricate roles of thyroid hormone receptors in human physiology and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRα1/β1 Antibody (C3) References:
- Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive. | Siesser, WB., et al. 2006. Genes Brain Behav. 5: 282-97. PMID: 16594981
- Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells. | Winter, H., et al. 2006. J Cell Sci. 119: 2975-84. PMID: 16803873
- Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis. | Kress, E., et al. 2010. Gastroenterology. 138: 1863-74. PMID: 20114049
- Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver. | Ramadoss, P., et al. 2014. J Biol Chem. 289: 1313-28. PMID: 24288132
- A histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant. | Kim, DW., et al. 2014. Hum Mol Genet. 23: 2651-64. PMID: 24381310
- Subchronic Exposure to Arsenic Represses the TH/TRβ1-CaMK IV Signaling Pathway in Mouse Cerebellum. | Guan, H., et al. 2016. Int J Mol Sci. 17: PMID: 26821021
- Overexpressing modified human TRβ1 suppresses the proliferation of breast cancer MDA-MB-468 cells. | Peng, X., et al. 2018. Oncol Lett. 16: 785-792. PMID: 29963146
- New Case of Thyroid Hormone Resistance α Caused by a Mutation of THRA /TRα1. | Sun, H., et al. 2019. J Endocr Soc. 3: 665-669. PMID: 30842990
- Relationship between the expression of TRβ1 and the molecular typing and clinicopathological features of breast cancer. | Miao, Y., et al. 2017. Int J Clin Exp Pathol. 10: 8875-8883. PMID: 31966755
- Suppression of Calcium Entry Modulates the Expression of TRβ1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels. | Asghar, MY., et al. 2022. Cancers (Basel). 14: PMID: 36497320
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRα1/β1 Antibody (C3) | sc-32754 | 200 µg/ml | $322.00 | |||
TRα1/β1 Antibody (C3): m-IgG Fc BP-HRP Bundle | sc-536746 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRα1/β1 Antibody (C3): m-IgGκ BP-HRP Bundle | sc-533907 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRα1/β1 Antibody (C3): m-IgG1 BP-HRP Bundle | sc-544792 | 200 µg Ab; 20 µg BP | $361.00 | |||
TRα1/β1 Antibody (C3) X | sc-32754 X | 200 µg/0.1 ml | $322.00 |