TRAIL Antibody (D-3): sc-8440

TRAIL Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects human TRAIL protein through western blotting, immunoprecipitation, immunofluorescence, and enzyme-linked immunosorbent assay. TRAIL (D-3) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. TRAIL, also known as TNF-related apoptosis-inducing ligand, plays a crucial role in the regulation of apoptosis, which is essential for maintaining cellular homeostasis and immune system function. TRAIL can trigger programmed cell death in cancer cells while sparing normal cells by binding to specific receptors, making TRAIL a significant focus in cancer therapy research. TRAIL′s ability to induce apoptosis in a selective manner highlights TRAIL′s potential as a therapeutic agent, as TRAIL may help eliminate malignant cells without adversely affecting healthy tissues. TRAIL belongs to the tumor necrosis factor (TNF) superfamily, which includes other important cytokines that mediate inflammation and immune responses. TRAIL is constitutively expressed in various tissues, unlike some TNF family members that are primarily expressed in activated T cells, underscoring TRAIL′s importance in both normal physiology and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TRAIL Antibody (D-3) References:

1. TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.  |  Plasilova, M., et al. 2002. Leukemia. 16: 67-73. PMID: 11840265
2. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.  |  Hyer, ML., et al. 2005. Cancer Res. 65: 4799-808. PMID: 15930300
3. Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation.  |  Micheau, O. 2018. Int J Mol Sci. 19: PMID: 29498673
4. TNF-Related Apoptosis-Inducing Ligand Receptor 1 in Patients With Ankylosing Spondylitis.  |  Karadag, DT., et al. 2020. J Clin Rheumatol. 26: 242-247. PMID: 31094932
5. Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes.  |  Fogarasi, M. and Dima, S. 2024. Cells. 13: PMID: 39451194
6. A family of ligands for the TNF receptor superfamily.  |  Cosman, D. 1994. Stem Cells. 12: 440-55. PMID: 7528588
7. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
8. Contenders in FasL/TNF death signaling.  |  Cleveland, JL. and Ihle, JN. 1995. Cell. 81: 479-82. PMID: 7758103
9. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
10. Transducers of life and death: TNF receptor superfamily and associated proteins.  |  Baker, SJ. and Reddy, EP. 1996. Oncogene. 12: 1-9. PMID: 8552378
11. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.  |  Pitti, RM., et al. 1996. J Biol Chem. 271: 12687-90. PMID: 8663110
12. Identification and characterization of a new member of the TNF family that induces apoptosis.  |  Wiley, SR., et al. 1995. Immunity. 3: 673-82. PMID: 8777713

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRAIL Antibody (D-3) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-TRAIL Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRAIL Antibody (D-3) Specifications

Alternate Product Name: TNFSF10

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 25-281

Epitope Target: TRAIL

Epitope Species: human

Product Reactivity/Detection: TRAIL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for TRAIL Antibody (D-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin