TOB2 Antibody (B-4): sc-515829

TOB2 Antibody (B-4) is a mouse monoclonal IgM antibody that detects TOB2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TOB2 antibody (B-4) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. TOB2 plays a crucial role in regulating cell cycle progression, particularly in the transition from G0/G1 phase to S phase, by interacting with the mammalian homologue of yeast Caf1. This function is vital for maintaining proper cellular proliferation and differentiation, which is especially significant in tissues such as skeletal muscle, thymus, and ovary where TOB2 is highly expressed. Additionally, TOB2 is implicated in the central nervous system, where TOB2 may contribute to the acquisition of motor skills. Understanding TOB2 dynamics and interactions can provide insights into various biological processes and potential therapeutic targets in diseases characterized by dysregulated cell growth.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TOB2 Antibody (B-4) References:

1. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.  |  Ikematsu, N., et al. 1999. Oncogene. 18: 7432-41. PMID: 10602502
2. Cloning and characterization of the mouse tob2 gene.  |  Ajima, R., et al. 2000. Gene. 253: 215-20. PMID: 10940559
3. Negative regulation of BMP/Smad signaling by Tob in osteoblasts.  |  Yoshida, Y., et al. 2000. Cell. 103: 1085-97. PMID: 11163184
4. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.  |  Tzachanis, D., et al. 2001. Nat Immunol. 2: 1174-82. PMID: 11694881
5. Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.  |  Suzuki, T., et al. 2002. Genes Dev. 16: 1356-70. PMID: 12050114
6. Identification of the Anti-proliferative protein Tob as a MAPK substrate.  |  Maekawa, M., et al. 2002. J Biol Chem. 277: 37783-7. PMID: 12151396
7. Nuclear localization of Tob is important for regulation of its antiproliferative activity.  |  Kawamura-Tsuzuku, J., et al. 2004. Oncogene. 23: 6630-8. PMID: 15235587
8. The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.  |  Jin, M., et al. 2005. Neuroscience. 131: 647-59. PMID: 15730870
9. Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation.  |  Chen, CA., et al. 2020. RNA. 26: 1143-1159. PMID: 32404348
10. Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.  |  Jiang, G., et al. 2020. J Immunol. 205: 981-986. PMID: 32611726
11. Hsa_circ_0086414/transducer of ERBB2 (TOB2) axis-driven lipid elimination and tumor suppression in clear cell renal cell cancer via perilipin 3.  |  Meng, X., et al. 2024. Int J Biol Macromol. 261: 129636. PMID: 38272402
12. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.  |  Matsuda, S., et al. 1996. Oncogene. 12: 705-13. PMID: 8632892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TOB2 Antibody (B-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TOB2 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TOB2 Antibody (B-4) Specifications

Alternate Product Name: TOB2

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 61-86

Epitope Target: TOB2

Epitope Species: human

Product Reactivity/Detection: TOB2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TOB2 Antibody (B-4): N/A