TNF-R2 Antibody (TR75-32): sc-12751

TNF-R2 Antibody (TR75-32) is a hamster monoclonal IgG antibody that detects TNF-R2 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. TNF-R2, also known as tumor necrosis factor receptor 2, plays a crucial role in mediating the effects of tumor necrosis factor (TNF), a key cytokine involved in inflammation and immune responses. This receptor is primarily expressed on immune cells and is essential for regulating cell survival, proliferation, and differentiation. TNF-R2 signaling is associated with anti-apoptotic pathways, which can influence the outcome of various immune responses and contribute to the pathogenesis of autoimmune diseases and cancer. The interaction of TNF-R2 with TNF can lead to the recruitment of various signaling molecules, including TRAF2 and TRAF1, which are pivotal for downstream signaling cascades that promote cell survival and inflammatory responses. Understanding the dynamics of TNF-R2 and its interactions is vital for developing therapeutic strategies targeting inflammatory diseases and malignancies, making TNF-R2 monoclonal antibody (TR75-32) an invaluable tool for researchers studying these complex biological processes.

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TNF-R2 Antibody (TR75-32) References:

1. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.  |  Fotin-Mleczek, M., et al. 2002. J Cell Sci. 115: 2757-70. PMID: 12077366
2. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue.  |  Ermert, M., et al. 2003. Cytokine. 22: 89-100. PMID: 12849708
3. Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation.  |  Carpentier, I., et al. 2008. Biochem Biophys Res Commun. 374: 752-7. PMID: 18671942
4. Anti-inflammatory effects of tumour necrosis factor (TNF)-alpha are mediated via TNF-R2 (p75) in tolerogenic transforming growth factor-beta-treated antigen-presenting cells.  |  Masli, S. and Turpie, B. 2009. Immunology. 127: 62-72. PMID: 18795974
5. Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficient mice.  |  Patel, A., et al. 2010. Brain Behav Immun. 24: 1276-80. PMID: 20685290
6. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis.  |  Chen, H., et al. 2013. Rheumatol Int. 33: 1223-7. PMID: 23052485
7. TNF-R2 in tumor microenvironment as prognostic factor in epithelial ovarian cancer.  |  Nomelini, RS., et al. 2018. Clin Exp Med. 18: 547-554. PMID: 29802567
8. A trivalent TNF-R2 as a new tumor necrosis factor alpha-blocking molecule.  |  Contreras, MA., et al. 2021. Proteins. 89: 1557-1564. PMID: 34250652
9. Cytokine priming reduces dependence on TNF-R2 for TNF-alpha-mediated induction of macrophage nitric oxide generation.  |  Miller, AR., et al. 1996. J Interferon Cytokine Res. 16: 1055-63. PMID: 8974009
10. Antioestrogens enhance tumour necrosis factor receptor 2 (TNF-R2) expression and TNF-R2-mediated proliferation in activated T cells.  |  Komi, J. and Lassila, O. 1998. Scand J Immunol. 48: 254-60. PMID: 9743209

The preferred TNF-R2 antibody is TNF-R2 Antibody (D-2): sc-8041.