TMEM102 Antibody (F-11): sc-398468

TMEM102 Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMEM102 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEM102 (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM102 protein, consisting of 508 amino acids, plays a crucial role in cellular processes, particularly in membrane trafficking and endosomal function regulation. Proper endosomal function is essential for maintaining cellular homeostasis and facilitating misfolded protein degradation, which can otherwise lead to cellular stress and contribute to neurodegenerative diseases. TMEM102 gene is located on human chromosome 17, a region significant for association with key tumor suppressor genes like p53 and BRCA1 and involvement in various genetic disorders. TMEM102 presence in endosomal compartments highlights potential roles in disease pathogenesis linked to endosomal dysfunction, making TMEM102 a valuable target for research in both cancer biology and neurodegenerative conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TMEM102 Antibody (F-11) References:

1. Birt-Hogg-Dubé Syndrome.  |  Welsch, MJ., et al. 2005. Int J Dermatol. 44: 668-73. PMID: 16101870
2. BLIMP1 regulates cell growth through repression of p53 transcription.  |  Yan, J., et al. 2007. Proc Natl Acad Sci U S A. 104: 1841-6. PMID: 17264218
3. Neurofibromatosis 1, and Not TP53, seems to be the main target of chromosome 17 deletions in de novo acute myeloid leukemia.  |  Suela, J., et al. 2007. J Clin Oncol. 25: 1151-2; author reply 1152-3. PMID: 17369586
4. Quantification of N-acetylaspartic acid in urine by LC-MS/MS for the diagnosis of Canavan disease.  |  Al-Dirbashi, OY., et al. 2007. J Inherit Metab Dis. 30: 612. PMID: 17632691
5. Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes.  |  Farrell, CJ. and Plotkin, SR. 2007. Neurol Clin. 25: 925-46, viii. PMID: 17964021
6. Breast cancer risk among male BRCA1 and BRCA2 mutation carriers.  |  Tai, YC., et al. 2007. J Natl Cancer Inst. 99: 1811-4. PMID: 18042939
7. Novel deletion mutation in GFAP gene in an infantile form of Alexander disease.  |  Murakami, N., et al. 2008. Pediatr Neurol. 38: 50-2. PMID: 18054694
8. Strategies for ovarian cancer prevention.  |  Dann, RB., et al. 2007. Obstet Gynecol Clin North Am. 34: 667-86, viii. PMID: 18061863
9. Susceptibility to breast cancer: hereditary syndromes and low penetrance genes.  |  Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TMEM102 Antibody (F-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TMEM102 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TMEM102 Antibody (F-11) Specifications

Alternate Product Name: TMEM102

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 421-498

Epitope Target: TMEM102

Epitope Species: human

Product Reactivity/Detection: TMEM102

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TMEM102 Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin