TM Antibody (H-11): sc-271804
- TM Antibody (H-11) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 547-575 at the C-terminus of TM of human origin
- Anti-TM Antibody (H-11) is recommended for detection of thrombomodulin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TM Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TM Antibody (H-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with TM Antibody (H-11) (see ordering information below).
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SEE ALSO...
TM Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects thrombomodulin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-thrombomodulin antibody (H-11) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental needs. Thrombomodulin, also known as CD141, is a type I membrane receptor predominantly found on endothelial cells, where thrombomodulin plays a crucial role in coagulation regulation. Thrombomodulin features a cysteine-rich extracellular domain with six epidermal growth factor-like regions, which are essential for interaction with thrombin. This interaction activates protein C, leading to the generation of activated protein C (APC), an important anticoagulant enzyme that, in conjunction with protein S, inhibits coagulation by inactivating factors Va and VIIIa. Deletion of the thrombomodulin gene results in embryonic lethality in mice, highlighting thrombomodulin′s essential role in vascular biology and coagulation homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TM Antibody (H-11) References:
- Soluble thrombomodulin and coronary heart disease. | Wu, KK. 2003. Curr Opin Lipidol. 14: 373-5. PMID: 12865735
- The role of thrombomodulin in malignancy. | Hanly, AM. and Winter, DC. 2007. Semin Thromb Hemost. 33: 673-9. PMID: 18000794
- Recombinant thrombomodulin monotherapy for secondary thrombotic thrombocytopenic purpura. | Ebisawa, K., et al. 2015. Am J Emerg Med. 33: 599.e1-3. PMID: 25266770
- Exploring traditional and nontraditional roles for thrombomodulin. | Loghmani, H. and Conway, EM. 2018. Blood. 132: 148-158. PMID: 29866818
- Thrombomodulin and multiorgan failure in sickle cell anemia. | Ruiz, MA., et al. 2022. Am J Hematol. 97: E102-E105. PMID: 34929051
- Thrombomodulin and pregnancy in the limelight: Insights into the therapeutic aspect of thrombomodulin in pregnancy complications. | Oda, H., et al. 2022. J Thromb Haemost. 20: 1040-1055. PMID: 35191182
- On the relevance of thrombomodulin variants in atypical hemolytic uremic syndrome. | Huerta, A., et al. 2023. Kidney Int. 104: 851-855. PMID: 37567446
- Thrombomodulin Regulates PTEN/AKT Signaling Axis in Endothelial Cells. | Giri, H., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 352-365. PMID: 38059351
- Thrombomodulin Improves Cognitive Deficits in Heat-Stressed Mice. | Lin, CH., et al. 2024. Int J Neuropsychopharmacol. 27: PMID: 38938182
- Thrombomodulin activity and localization. | Fink, LM., et al. 1993. Int J Dev Biol. 37: 221-6. PMID: 8389578
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TM Antibody (H-11) | sc-271804 | 200 µg/ml | $316.00 | |||
TM Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-525824 | 200 µg Ab; 10 µg BP | $354.00 | |||
TM Antibody (H-11) AC | sc-271804 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TM Antibody (H-11) HRP | sc-271804 HRP | 200 µg/ml | $316.00 | |||
TM Antibody (H-11) FITC | sc-271804 FITC | 200 µg/ml | $330.00 | |||
TM Antibody (H-11) PE | sc-271804 PE | 200 µg/ml | $343.00 | |||
TM Antibody (H-11) Alexa Fluor® 488 | sc-271804 AF488 | 200 µg/ml | $357.00 | |||
TM Antibody (H-11) Alexa Fluor® 546 | sc-271804 AF546 | 200 µg/ml | $357.00 | |||
TM Antibody (H-11) Alexa Fluor® 594 | sc-271804 AF594 | 200 µg/ml | $357.00 | |||
TM Antibody (H-11) Alexa Fluor® 647 | sc-271804 AF647 | 200 µg/ml | $357.00 | |||
TM Antibody (H-11) Alexa Fluor® 680 | sc-271804 AF680 | 200 µg/ml | $357.00 | |||
TM Antibody (H-11) Alexa Fluor® 790 | sc-271804 AF790 | 200 µg/ml | $357.00 | |||
TM (H-11) Neutralizing Peptide | sc-271804 P | 100 µg/0.5 ml | $68.00 |