TLR8 Antibody (D-8): sc-373760

TLR8 Antibody (D-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects TLR8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TLR8 (D-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TLR8 plays a crucial role in the innate immune system by recognizing viral RNA, which is essential for initiating an immune response against viral infections. Located primarily in lung tissue and peripheral blood leukocytes, TLR8 is part of a subfamily of Toll-like receptors that includes TLR7 and TLR9, all of which are involved in activating the NFκB signaling pathway. This pathway is vital for the transcription of pro-inflammatory cytokines, thereby enhancing the immune response. The ability of TLR8 to detect viral components and trigger immune signaling underscores its importance in host defense mechanisms, making anti-TLR8 antibody (D-8) a valuable tool for researchers studying immune responses and potential therapeutic targets in viral infections.

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TLR8 Antibody (D-8) References:

1. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.  |  Brightbill, HD., et al. 1999. Science. 285: 732-6. PMID: 10426995
2. Three novel mammalian toll-like receptors: gene structure, expression, and evolution.  |  Du, X., et al. 2000. Eur Cytokine Netw. 11: 362-71. PMID: 11022119
3. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.  |  Chuang, TH. and Ulevitch, RJ. 2000. Eur Cytokine Netw. 11: 372-8. PMID: 11022120
4. Drosophila Toll and IL-1 receptor.  |  Gay, NJ. and Keith, FJ. 1991. Nature. 351: 355-6. PMID: 1851964
5. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy.  |  Smits, EL., et al. 2008. Oncologist. 13: 859-75. PMID: 18701762
6. MicroRNA21 Meets Neuronal TLR8: Non-canonical Functions of MicroRNA in Neuropathic Pain.  |  Wang, ZH. and Liu, T. 2019. Neurosci Bull. 35: 949-952. PMID: 30887247
7. Targeting the innate immune receptor TLR8 using small-molecule agents.  |  Sakaniwa, K. and Shimizu, T. 2020. Acta Crystallogr D Struct Biol. 76: 621-629. PMID: 32627735
8. TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins.  |  Fejtkova, M., et al. 2022. Am J Hematol. 97: 338-351. PMID: 34981838
9. CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.  |  Yang, C., et al. 2022. Nat Commun. 13: 3426. PMID: 35701499
10. LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8.  |  Allen, RM., et al. 2022. Nat Cell Biol. 24: 1701-1713. PMID: 36474072
11. TBK1 and Caspase-8 suppress necroptosis but activate NLRP3 inflammasome activation during CXCL4 and TLR8 costimulation.  |  Cui, Y., et al. 2024. Cell Death Discov. 10: 511. PMID: 39715768
12. A family of human receptors structurally related to Drosophila Toll.  |  Rock, FL., et al. 1998. Proc Natl Acad Sci U S A. 95: 588-93. PMID: 9435236

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR8 Antibody (D-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR8 Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR8 Antibody (D-8) Specifications

Alternate Product Name: TLR8

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 27-140

Epitope Target: TLR8

Epitope Species: human

Product Reactivity/Detection: TLR8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TLR8 Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred TLR8 antibody is TLR8 Antibody (9A6): sc-135584.