Date published: 2025-10-16

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TLR8 Antibody (9A6): sc-135584

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Datasheets
  • TLR8 Antibody (9A6) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 100 µg/ml
  • raised against recombinant TLR8 protein of human origin
  • recommended for detection of TLR8 of human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TLR8 Antibody (9A6). This work is in progress.

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TLR8 Antibody (9A6) is a mouse monoclonal IgG2b kappa light chain antibody that detects TLR8 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-TLR8 antibody (9A6) is available in a non-conjugated form, allowing for versatile applications in research. TLR8, a member of the Toll-like receptor family, plays a crucial role in the innate immune system by recognizing viral RNA and initiating immune responses. TLR8 is primarily located in the endosomal compartments of immune cells, where TLR8 detects pathogens and triggers signaling pathways that lead to the production of pro-inflammatory cytokines. The proper functioning of TLR8 is vital for the host′s defense against viral infections, as TLR8 helps to activate the NFκB signaling pathway, which is essential for mounting an effective immune response. Dysregulation of TLR8 can lead to inadequate immune responses or excessive inflammation, highlighting TLR8′s importance in maintaining immune homeostasis. TLR8 monoclonal antibody (9A6) is an invaluable tool for researchers studying immune responses and the mechanisms of viral recognition.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

TLR8 Antibody (9A6) References:

  1. The Relevance of TLR8 in Viral Infections.  |  Martínez-Espinoza, I. and Guerrero-Plata, A. 2022. Pathogens. 11: PMID: 35215078
  2. Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.  |  Peng, C., et al. 2023. J Hypertens. 41: 1245-1257. PMID: 37199563
  3. Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice.  |  Maria, NI., et al. 2023. Life Sci Alliance. 6: PMID: 37495396
  4. TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.  |  Kong, X., et al. 2024. Rheumatology (Oxford). 63: 1710-1719. PMID: 37665747
  5. TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells.  |  Youness, A., et al. 2023. Biol Sex Differ. 14: 60. PMID: 37723501
  6. Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.  |  Gane, EJ., et al. 2023. J Hepatol. 78: 513-523. PMID: 38133554
  7. MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus.  |  Wang, T., et al. 2024. Cell Commun Signal. 22: 220. PMID: 38589923
  8. TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.  |  Roca Suarez, AA., et al. 2024. Gut. 73: 2012-2022. PMID: 38697771
  9. Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.  |  Zheng, W., et al. 2024. Int J Biol Macromol. 269: 132018. PMID: 38702002
  10. Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.  |  Liang, J., et al. 2024. Nat Commun. 15: 5678. PMID: 38971858

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TLR8 Antibody (9A6)

sc-135584
100 µg/ml
$333.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with TLR8 (9A6): sc-135584 antibody?

Asked by: Cweed
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
  • y_2025, m_10, d_14, h_6CST
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Rated 1 out of 5 by from Funktioniert leider nicht bei mir im WB.AK wurde in einer 1:200-Verdünnung im WB an stabil mit TLR8 transduzierten Hek-Zellen getestet. Leider konnte ich keine Bande in der richtigen Größe detektieren.
Date published: 2018-05-30
Rated 3 out of 5 by from Worked with human transfected lysate by WBWorked with human transfected lysate by WB. -SCBT QC
Date published: 2015-04-20
Rated 4 out of 5 by from Positive WB data in THPPositive WB data in THP-1 whole cell lysate. -SCBT QC
Date published: 2013-05-24
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TLR8 Antibody (9A6) is rated 2.7 out of 5 by 3.
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