TLR5 Antibody (85B152.5): sc-52963
- TLR5 Antibody (85B152.5) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 100 µg/ml
- raised against synthetic TLR5 of human origin
- recommended for detection of TLR5 of mouse, rat and human origin by WB and FCM; also reactive with additional species, including canine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TLR5 Antibody (85B152.5). This work is in progress.
TLR5 Antibody (85B152.5) is a mouse monoclonal IgG2a antibody that detects TLR5 in mouse, rat, and human samples through applications such as western blotting (WB) and flow cytometry (FCM). TLR5, a member of the Toll-like receptor family, plays a crucial role in the innate immune response by recognizing bacterial flagellin, a key component of flagella, which is essential for motility in many pathogenic bacteria. Upon binding to flagellin, TLR5 initiates a signaling cascade that activates nuclear factor kappa B (NFκB) and other transcription factors, leading to the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of infection. This process is vital for the host′s defense against bacterial infections, as TLR5 helps to establish an effective immune response. TLR5 is predominantly expressed in the ovary and peripheral blood leukocytes, particularly in monocytes, and is also found in lower levels in the prostate and testis. TLR5′s ability to detect flagellated bacteria underscores its importance in the immune system′s ability to distinguish between self and non-self, making TLR5 a significant target for research in immunology and infectious diseases.
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TLR5 Antibody (85B152.5) References:
- Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin. | Tsujita, T., et al. 2006. Vaccine. 24: 2193-9. PMID: 16314010
- Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients. | Stanislawowski, M., et al. 2009. J Physiol Pharmacol. 60 Suppl 4: 71-5. PMID: 20083854
- Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. | Lopetuso, LR., et al. 2017. Inflamm Bowel Dis. 23: 392-403. PMID: 28146004
- Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis. | Birnie, E., et al. 2019. Infect Immun. 87: PMID: 31109950
- TLR-4, TLR-5 and IRF4 are diagnostic markers of knee osteoarthritis in the middle-aged and elderly patients and related to disease activity and inflammatory factors. | Han, W., et al. 2020. Exp Ther Med. 20: 1291-1298. PMID: 32765669
- Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms. | Kurz, B., et al. 2022. J Eur Acad Dermatol Venereol. 36: 2172-2180. PMID: 35748133
- TLR5-Derived, TIR-Interacting Decoy Peptides to Inhibit TLR Signaling. | Javmen, A., et al. 2023. J Immunol. 210: 1419-1427. PMID: 36946775
- Masking of typical TLR4 and TLR5 ligands modulates inflammation and resolution by Helicobacter pylori. | Pachathundikandi, SK., et al. 2023. Trends Microbiol. 31: 903-915. PMID: 37012092
- TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity. | Feng, S., et al. 2023. J Inflamm Res. 16: 2491-2501. PMID: 37337514
- Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food. | Kemter, AM., et al. 2023. Cell Rep. 42: 113153. PMID: 37742185
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLR5 Antibody (85B152.5) | sc-52963 | 100 µg/ml | $333.00 |