TLR1 Antibody (H-8): sc-514399

TLR1 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TLR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TLR1 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TLR1 plays a crucial role in the immune system by recognizing pathogen-associated molecular patterns, which is essential for initiating innate immune responses. Specifically, TLR1 forms a heterodimer with TLR2, allowing for the detection of triacylated lipopeptides from bacteria, leading to the activation of downstream signaling pathways that result in the production of pro-inflammatory cytokines. This function is vital for host defense against infections, as TLR1 helps orchestrate immune response and promote inflammation necessary for clearing pathogens. TLR1 is characterized by a highly conserved Toll homology domain critical for signal transduction and is predominantly expressed in peripheral blood leukocytes, macrophages, and monocytes, highlighting TLR1′s importance in immune surveillance. Additionally, TLR1 shares significant sequence homology with TLR6, which also participates in immune signaling, further emphasizing the interconnectedness of TLR family members in mediating inflammatory responses.

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TLR1 Antibody (H-8) References:

1. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.  |  Chow, JC., et al. 1999. J Biol Chem. 274: 10689-92. PMID: 10196138
2. TLR6: A novel member of an expanding toll-like receptor family.  |  Takeuchi, O., et al. 1999. Gene. 231: 59-65. PMID: 10231569
3. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2.  |  Schwandner, R., et al. 1999. J Biol Chem. 274: 17406-9. PMID: 10364168
4. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.  |  Brightbill, HD., et al. 1999. Science. 285: 732-6. PMID: 10426995
5. Drosophila Toll and IL-1 receptor.  |  Gay, NJ. and Keith, FJ. 1991. Nature. 351: 355-6. PMID: 1851964
6. TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.  |  Oosting, M., et al. 2011. PLoS One. 6: e25998. PMID: 21998742
7. TLR1-10, NF-κB and p53 expression is increased in oral lichenoid disease.  |  Rusanen, P., et al. 2017. PLoS One. 12: e0181361. PMID: 28715461
8. TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.  |  Sharma, N., et al. 2019. Proc Natl Acad Sci U S A. 116: 10453-10462. PMID: 31076558
9. NHWD-1062 ameliorates inflammation and proliferation by the RIPK1/NF-κB/TLR1 axis in Psoriatic Keratinocytes.  |  Guo, Y., et al. 2023. Biomed Pharmacother. 162: 114638. PMID: 37011486
10. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.  |  Medzhitov, R., et al. 1997. Nature. 388: 394-7. PMID: 9237759
11. A family of human receptors structurally related to Drosophila Toll.  |  Rock, FL., et al. 1998. Proc Natl Acad Sci U S A. 95: 588-93. PMID: 9435236
12. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.  |  Yang, RB., et al. 1998. Nature. 395: 284-8. PMID: 9751057

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR1 Antibody (H-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR1 Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR1 Antibody (H-8) Specifications

Alternate Product Name: TLR1

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 161-250

Epitope Target: TLR1

Epitope Species: human

Product Reactivity/Detection: TLR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TLR1 Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin