Tip41 Antibody (B-3): sc-398145

Tip41 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tip41 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Tip41 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tip41 protein, also known as TOR signaling pathway regulator-like (S. cerevisiae), TIPRL, or putative MAPK-activating protein PM10, is a 272 amino acid protein that plays a crucial role in cellular signaling pathways. Tip41 is primarily located in the cytoplasm and exists in two alternatively spliced isoforms, which allows for functional diversity in regulatory roles. Tip41 becomes phosphorylated in response to DNA damage, suggesting involvement in cellular stress responses and regulation of the ATM/ATR signaling pathway, which is essential for maintaining genomic stability during DNA replication and repair. The gene encoding Tip41 is located on human chromosome 1q24.2 and mouse chromosome 1 H2.3, highlighting evolutionary conservation and significance across species. Chromosome 1 is the largest human chromosome, encompassing approximately 260 million base pairs and containing around 3,000 genes, many of which are implicated in various diseases, including Stickler syndrome, Parkinson′s disease, and Gaucher disease. Tip41′s ability to interact with key regulatory proteins such as PP2A-Cα/β, PPX, and PP6 further underscores importance in cellular signaling and potential implications in therapeutic strategies targeting these pathways.

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Tip41 Antibody (B-3) References:

1. Two novel polymorphic sequences in the glucocerebrosidase gene region enhance mutational screening and founder effect studies of patients with Gaucher disease.  |  Lau, EK., et al. 1999. Hum Genet. 104: 293-300. PMID: 10369158
2. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.  |  Jacinto, E., et al. 2001. Mol Cell. 8: 1017-26. PMID: 11741537
3. Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.  |  Oliveira, SA., et al. 2005. Am J Hum Genet. 77: 252-64. PMID: 15986317
4. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
5. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.  |  McConnell, JL., et al. 2007. Oncogene. 26: 6021-30. PMID: 17384681
6. Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL).  |  Smetana, JH. and Zanchin, NI. 2007. FEBS J. 274: 5891-904. PMID: 17944932
7. Fas-associated factor 1 and Parkinson's disease.  |  Betarbet, R., et al. 2008. Neurobiol Dis. 31: 309-15. PMID: 18573343
8. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.  |  Cheung, CL., et al. 2009. Hum Mol Genet. 18: 679-87. PMID: 19064610
9. Analysis of the vitreous membrane in a case of type 1 Stickler syndrome.  |  Yokoi, T., et al. 2009. Graefes Arch Clin Exp Ophthalmol. 247: 715-8. PMID: 19089441

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tip41 Antibody (B-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Tip41 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tip41 Antibody (B-3) Specifications

Alternate Product Name: Tip41

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-180

Epitope Target: Tip41

Epitope Species: human

Product Reactivity/Detection: Tip41

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Tip41 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin