TIMP-2 Antibody (H-4): sc-271932

TIMP-2 Antibody (H-4) is a mouse monoclonal IgG2a antibody that detects TIMP-2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TIMP-2, or tissue inhibitor of metalloproteinase 2, plays a crucial role in regulating extracellular matrix remodeling by inhibiting metalloproteinases, which are enzymes responsible for the degradation of various components of the extracellular matrix. This regulation is vital for maintaining tissue homeostasis and facilitating processes such as wound healing and embryonic development. TIMP-2 is predominantly expressed in tissues such as the heart, kidney, and lung, where TIMP-2 helps control cellular processes essential for organ function and integrity. TIMP-2′s interaction with metalloproteinases not only prevents excessive tissue breakdown but also influences cellular signaling pathways that can affect cell proliferation and apoptosis. Anti-TIMP-2 antibody (H-4) enables researchers to gain insights into the dynamics of tissue remodeling and pathological processes associated with diseases such as cancer and fibrosis, making this research tool invaluable for advancing our understanding of these critical biological functions.

The preferred TIMP-2 antibody is TIMP-2 Antibody (3A4): sc-21735.