Tim8A Antibody (T-40): sc-101282
- Tim8A Antibody (T-40) is a mouse monoclonal IgG2a κ Tim8A antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Tim8A of human origin
- recommended for detection of Tim8A of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tim8A Antibody (T-40). This work is in progress.
Tim8A Antibody (T-40) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tim8A protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Tim8A antibody (T-40) is available in non-conjugated form. Tim8A protein functions critically in mitochondrial processes, specifically importing nuclear-encoded precursor proteins into mitochondria to maintain integrity and function. Tim8A (T-40) monoclonal antibody recognizes a protein essential for cellular energy production and metabolic pathway regulation. Tim8A belongs to the mitochondrial Tim protein family, facilitating protein translocation across mitochondrial inner membranes via Tim23 and Tim22 complexes. Tim8A (T-40) antibody targets a protein whose mutations link to deafness dystonia syndrome, causing severe neurological defects. Tim8A shows high expression in fetal and adult brain tissue, indicating significant involvement in neural function and development.
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Tim8A Antibody (T-40) References:
- Human deafness dystonia syndrome is a mitochondrial disease. | Koehler, CM., et al. 1999. Proc Natl Acad Sci U S A. 96: 2141-6. PMID: 10051608
- The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. | Jin, H., et al. 1999. Genomics. 61: 259-67. PMID: 10552927
- The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. | Bauer, MF., et al. 1999. FEBS Lett. 464: 41-7. PMID: 10611480
- The role of the TIM8-13 complex in the import of Tim23 into mitochondria. | Paschen, SA., et al. 2000. EMBO J. 19: 6392-400. PMID: 11101512
- Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration. | Bauer, MF. and Neupert, W. 2001. J Inherit Metab Dis. 24: 166-80. PMID: 11405338
- The preprotein translocase of the mitochondrial inner membrane: function and evolution. | Rassow, J., et al. 1999. J Mol Biol. 286: 105-20. PMID: 9931253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tim8A Antibody (T-40) | sc-101282 | 100 µg/ml | $333.00 |