Tim8A Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP uncouples oxidative phosphorylation, leading to a reduction in ATP synthesis. Tim8A, being involved in mitochondrial protein import, relies on the electrochemical gradient that is dissipated by FCCP, thereby inhibiting its function. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A inhibits ATP synthase in mitochondria. Since Tim8A function is energy-dependent, the inhibition of ATP synthase by Oligomycin A can lead to decreased ATP levels and thus inhibit Tim8A's activity in mitochondrial protein import. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III. This inhibition disrupts mitochondrial membrane potential, essential for Tim8A-mediated import of proteins into mitochondria, thus inhibiting Tim8A function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of complex I in the mitochondrial electron transport chain. By impeding the electron flow, it decreases the mitochondrial membrane potential required for Tim8A to import proteins into mitochondria. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
TTFA (thenoyltrifluoroacetone) inhibits mitochondrial complex II. This inhibition can reduce the activity of Tim8A by diminishing the mitochondrial membrane potential necessary for its protein import function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Chloride can inhibit mitochondrial import by competing with metal ions that are cofactors for mitochondrial import proteins, including Tim8A. This competition can impair Tim8A's function in importing proteins into the mitochondria. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat generates reactive oxygen species within mitochondria, leading to oxidative stress. This stress can damage the mitochondrial transport system, including Tim8A, thereby inhibiting its protein import function. | ||||||
α-Cyano-4-hydroxycinnamic acid | 28166-41-8 | sc-254923 | 2 g | $43.00 | 2 | |
This compound is an inhibitor of the mitochondrial pyruvate carrier. It can decrease mitochondrial metabolism and reduce the membrane potential, indirectly inhibiting Tim8A's ability to import proteins into the mitochondria. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium Chloride can displace metal ions essential for the structure and function of various mitochondrial proteins, including Tim8A. This displacement can inhibit the protein import functionality of Tim8A. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits thioredoxin reductase, which is involved in maintaining the redox environment of the cell. A more oxidizing environment can affect the function of Tim8A, which relies on a reduced environment for proper folding and function. | ||||||