TIEG2 Antibody (32): sc-136101

TIEG2 Antibody (32) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIEG2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-TIEG2 antibody (32) is available as the non-conjugated format. TIEG2, a member of the Krüppel-like zinc finger transcription factor family, plays a crucial role in regulating cellular growth and differentiation, particularly in response to transforming growth factor beta (TGFβ). TIEG2 is predominantly located in the nucleus, where TIEG2 influences gene expression and cellular processes. Nuclear localization is vital for function as a transcription factor, allowing TIEG2 to interact with specific DNA sequences and modulate transcription of target genes involved in cell cycle regulation and apoptosis. TIEG2 is expressed in fetal liver and has been shown to inhibit cellular proliferation when overexpressed in cultured epithelial cells, highlighting potential role in developmental processes and tissue homeostasis. TIEG2 expression is upregulated by TGFβ1 and serum deprivation, indicating involvement in cellular responses to environmental changes. With detection capabilities across multiple species and applications, TIEG2 (32) monoclonal antibody serves as an essential tool for researchers studying molecular mechanisms underlying cell growth and differentiation.

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TIEG2 Antibody (32) References:

1. FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.  |  Asano, H., et al. 1999. Mol Cell Biol. 19: 3571-9. PMID: 10207080
2. Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor.  |  Ellenrieder, V., et al. 2002. EMBO J. 21: 2451-60. PMID: 12006497
3. Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.  |  Ou, XM., et al. 2004. J Biol Chem. 279: 21021-8. PMID: 15024015
4. The effect of hypoxia and stem cell source on haemoglobin switching.  |  Narayan, AD., et al. 2005. Br J Haematol. 128: 562-70. PMID: 15686468
5. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.  |  Neve, B., et al. 2005. Proc Natl Acad Sci U S A. 102: 4807-12. PMID: 15774581
6. A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.  |  Zhang, P., et al. 2005. Blood Cells Mol Dis. 35: 227-35. PMID: 16023392
7. {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice.  |  Blau, CA., et al. 2005. J Biol Chem. 280: 36642-7. PMID: 16131492

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIEG2 Antibody (32) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TIEG2 Antibody (32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIEG2 Antibody (32) Specifications

Alternate Product Name: TIEG2

Product Clone Name: 32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 101-219

Epitope Target: TIEG2

Epitope Species: human

Product Reactivity/Detection: TIEG2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TIEG2 Antibody (32): N/A