TIEG1 Antibody (95-D): sc-130408

TIEG1 Antibody (95-D) is a mouse monoclonal IgG2b kappa light chain antibody that detects TIEG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TIEG1 (95-D) antibody is available as the non-conjugated form. TGFβ-inducible early gene-1 (TIEG1) is a crucial transcription factor that plays a significant role in regulating cellular growth and differentiation, particularly in response to TGFβ1 signaling. TIEG1 is primarily located in the nucleus, where TIEG1 functions as a transcriptional regulator, influencing gene expression patterns vital for cellular responses to environmental cues. Nuclear localization of TIEG1 is essential for mediating TGFβ effects, as TIEG1 interacts with specific DNA sequences and recruits other transcriptional co-factors. TIEG1 is expressed in various tissues, including acinar and ductular epithelial cells of the exocrine pancreas, with particularly high expression in human fetal osteoblast cells, peripheral blood leukocytes, spleen, and colon. TIEG1′s ability to induce apoptosis in TGFβ-sensitive epithelial cells underscores TIEG1′s importance in regulating cell fate decisions. TIEG1 and EGRa are expressed from alternate promoters of the same gene, highlighting the complexity of gene regulation in this context. TIEG1′s presence in multiple tissues and regulatory functions make TIEG1 a critical player in developmental processes and tissue homeostasis.

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TIEG1 Antibody (95-D) References:

1. FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.  |  Asano, H., et al. 1999. Mol Cell Biol. 19: 3571-9. PMID: 10207080
2. Role of TIEG1 in biological processes and disease states.  |  Subramaniam, M., et al. 2007. J Cell Biochem. 102: 539-48. PMID: 17729309
3. TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4.  |  Li, Q., et al. 2015. J Cardiovasc Pharmacol. 66: 196-203. PMID: 26252173
4. TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts.  |  Subramaniam, M., et al. 2016. Biochem Biophys Res Commun. 470: 528-533. PMID: 26801561
5. TIEG1 Represses Smad7-Mediated Activation of TGF-β1/Smad Signaling in Keloid Pathogenesis.  |  Hu, ZC., et al. 2017. J Invest Dermatol. 137: 1051-1059. PMID: 28108300
6. TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone.  |  Subramaniam, M., et al. 2017. Nucleic Acids Res. 45: 5170-5182. PMID: 28201653
7. TIEG1 is upregulated in Lrp5/6-mediated valve osteogenesis.  |  Rajamannan, NM. 2019. J Cell Biochem. 120: 3362-3366. PMID: 30246479
8. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.  |  Subramaniam, M., et al. 1995. Nucleic Acids Res. 23: 4907-12. PMID: 8532536
9. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation.  |  Blok, LJ., et al. 1995. Mol Endocrinol. 9: 1610-20. PMID: 8584037
10. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.  |  Tachibana, I., et al. 1997. J Clin Invest. 99: 2365-74. PMID: 9153278
11. Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts.  |  Fautsch, MP., et al. 1998. Mamm Genome. 9: 838-42. PMID: 9745041
12. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.  |  Cook, T., et al. 1998. J Biol Chem. 273: 25929-36. PMID: 9748269

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TIEG1 Antibody (95-D) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-TIEG1 Antibody (95-D) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TIEG1 Antibody (95-D) Specifications

Alternate Product Name: TIEG1

Product Clone Name: 95-D

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-110

Epitope Target: TIEG1

Epitope Species: human

Product Reactivity/Detection: TIEG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for TIEG1 Antibody (95-D): N/A