TICAM-2 Antibody (E-2): sc-376076
- TICAM-2 Antibody (E-2) is a mouse monoclonal IgG2b κ TICAM-2 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 142-226 mapping near the C-terminus of TICAM-2 of human origin
- TICAM-2 Antibody (E-2) is recommended for detection of TICAM-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TICAM-2 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for TICAM-2 Antibody (E-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with TICAM-2 Antibody (E-2) (see ordering information below).
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TICAM-2 Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects TICAM-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TICAM-2 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TICAM-2, also known as TRAM or TIRAP3, plays a crucial role in the immune response by acting as a signaling adapter that connects Toll-like receptor 4 (TLR4) to TICAM-1, thereby facilitating the transmission of lipopolysaccharide (LPS) signaling. This interaction is vital for the activation of interferon regulatory factor 3 (IRF-3), which subsequently leads to the production of type I interferons, essential for antiviral defense. TICAM-2′s proper functioning ensures an effective immune response against pathogens, linking innate and adaptive immunity. Additionally, TICAM-2′s structural similarity to Mal/TIRAP highlights its importance in the TLR signaling pathway, underscoring its role in mediating the immune system′s response to various stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TICAM-2 Antibody (E-2) References:
- Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. | Yamamoto, M., et al. 2002. J Immunol. 169: 6668-72. PMID: 12471095
- TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. | Oshiumi, H., et al. 2003. Nat Immunol. 4: 161-7. PMID: 12539043
- TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. | Bin, LH., et al. 2003. J Biol Chem. 278: 24526-32. PMID: 12721283
- LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. | Fitzgerald, KA., et al. 2003. J Exp Med. 198: 1043-55. PMID: 14517278
- TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. | Oshiumi, H., et al. 2003. J Biol Chem. 278: 49751-62. PMID: 14519765
- TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons. | Seya, T., et al. 2005. Int J Biochem Cell Biol. 37: 524-9. PMID: 15618008
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TICAM-2 Antibody (E-2) | sc-376076 | 200 µg/ml | $322.00 | |||
TICAM-2 Antibody (E-2): m-IgG2b BP-HRP Bundle | sc-548751 | 200 µg Ab; 10 µg BP | $361.00 | |||
TICAM-2 Antibody (E-2) AC | sc-376076 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TICAM-2 Antibody (E-2) HRP | sc-376076 HRP | 200 µg/ml | $322.00 | |||
TICAM-2 Antibody (E-2) FITC | sc-376076 FITC | 200 µg/ml | $336.00 | |||
TICAM-2 Antibody (E-2) PE | sc-376076 PE | 200 µg/ml | $349.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 488 | sc-376076 AF488 | 200 µg/ml | $364.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 546 | sc-376076 AF546 | 200 µg/ml | $364.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 594 | sc-376076 AF594 | 200 µg/ml | $364.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 647 | sc-376076 AF647 | 200 µg/ml | $364.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 680 | sc-376076 AF680 | 200 µg/ml | $364.00 | |||
TICAM-2 Antibody (E-2) Alexa Fluor® 790 | sc-376076 AF790 | 200 µg/ml | $364.00 |