ThrRS Antibody (B-6): sc-166211

ThrRS Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects threonyl-tRNA synthetase (ThrRS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ThrRS plays a crucial role in protein synthesis by catalyzing the aminoacylation of tRNA with threonine, thereby ensuring accurate translation of genetic information into functional proteins. ThrRS (B-6) antibody recognizes a cytoplasmic enzyme essential for maintaining protein synthesis fidelity by linking specific amino acids to corresponding tRNA molecules used by ribosomes during translation. The structure of ThrRS features a zinc-binding catalytic domain, a C-terminal tRNA-binding domain, and an N-terminal editing domain, all contributing to function. ThrRS contains four mobile regions facilitating conformational changes during catalysis, allowing precise interaction between tRNA and threonine. These dynamic structural features enhance catalytic efficiency and prevent errors in protein synthesis, underscoring ThrRS importance in cellular function and overall organismal health.

The preferred ThrRS antibody is ThrRS Antibody (C-3): sc-166146.