Thrombin API Antibody (B-2): sc-373848
- Thrombin API Antibody (B-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 95-129 within an internal region of Thrombin Activation Peptide 1 of mouse origin
- recommended for detection of Thrombin API and Prothrombin of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Thrombin API Antibody (B-2) for WB applications. This reagent is now offered in a bundle with Thrombin API Antibody (B-2) (see ordering information below).
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Thrombin API Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects Thrombin in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Thrombin is a crucial serine protease in the coagulation cascade, primarily responsible for converting fibrinogen into fibrin, which is essential for blood clot formation. Beyond its role in hemostasis, anti-Thrombin antibody (B-2) influences various cellular processes, including cell proliferation and inflammation, by activating protease-activated receptors (PARs) on the surface of various cell types. This interaction is vital for maintaining vascular integrity and promoting wound healing, as Thrombin monoclonal antibody (B-2) helps regulate the balance between coagulation and fibrinolysis. Thrombin (B-2) antibody provides a reliable tool for researchers studying these complex biological processes, enabling a deeper understanding of Thrombin′s multifaceted roles in health and disease.
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Thrombin API Antibody (B-2) References:
- Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning. | Xi, G., et al. 1999. Stroke. 30: 1247-55. PMID: 10356108
- Thrombin-receptor activation and thrombin-induced brain tolerance. | Jiang, Y., et al. 2002. J Cereb Blood Flow Metab. 22: 404-10. PMID: 11919511
- Thrombin generation and presence of thrombin receptor in ovarian follicles. | Roach, LE., et al. 2002. Biol Reprod. 66: 1350-8. PMID: 11967197
- Thrombin as a proteolytic enzyme. | SHERRY, S., et al. 1954. Physiol Rev. 34: 736-41. PMID: 13215095
- Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors. | Gurm, HS. and Bhatt, DL. 2005. Am Heart J. 149: S43-53. PMID: 15644793
- Thrombin inhibition in subarachnoid hemorrhage. | Arnaout, O. and Bendok, BR. 2009. Neurosurgery. 65: N9-10. PMID: 19934959
- HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions. | Kretz, CA., et al. 2010. Thromb Haemost. 103: 83-93. PMID: 20062917
- Destabilization of β-amyloid aggregates by thrombin derived peptide: plausible role of thrombin in neuroprotection. | De, D., et al. 2020. FEBS J. 287: 2386-2413. PMID: 31747135
- Magnetic nanoparticles immobilized thrombin ligand fishing to screen thrombin inhibitors in natural products. | Guo, H., et al. 2024. J Pharm Biomed Anal. 243: 116110. PMID: 38513498
- Thrombin-Hirudin complex formation, thrombin-antithrombin III complex formation, and thrombin generation after intrinsic activation of plasma. | Gallistl, S. and Muntean, W. 1994. Thromb Haemost. 72: 387-92. PMID: 7855789
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombin API Antibody (B-2) | sc-373848 | 200 µg/ml | $316.00 | |||
Thrombin API Antibody (B-2): m-IgG2b BP-HRP Bundle | sc-548566 | 200 µg Ab; 10 µg BP | $354.00 | |||
Thrombin API (B-2) Neutralizing Peptide | sc-373848 P | 100 µg/0.5 ml | $68.00 |