Thiorphan (DL) (CAS 76721-89-6)
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Thiorphan (DL) is a potent inhibitor of neutral endopeptidase (NEP), also known as neprilysin, which is an enzyme responsible for the degradation of various biologically active peptides, including enkephalins. By inhibiting NEP, Thiorphan (DL) is used in research to elevate the levels of these peptides in the body and to study their effects on pain perception, opioid receptor binding, and the modulation of analgesic pathways. Research involving Thiorphan (DL) provides insights into the endogenous mechanisms of pain control and contributes to the understanding of how the body regulates peptide hormones that are implicated in various processes. Additionally, it aids in the exploration of the broader physiological roles of NEP, including its impact on blood pressure and fluid balance, by preventing the breakdown of natriuretic and vasodilatory peptides.
Thiorphan (DL) (CAS 76721-89-6) References
- Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats. | Belichard, P., et al. 1999. Br J Pharmacol. 128: 213-9. PMID: 10498854
- Metalloproteinase activity is the sole factor responsible for the growth-promoting effect of conditioned medium in Trichoplusia ni insect cell cultures. | Eriksson, U., et al. 2005. J Biotechnol. 119: 76-86. PMID: 16046243
- Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. | Amantini, C., et al. 2008. J Pharmacol Exp Ther. 327: 215-25. PMID: 18621988
- Unique pattern of cleavage of vasoactive intestinal peptide by human lymphocytes. | Goetzl, EJ., et al. 1989. Immunology. 66: 554-8. PMID: 2654011
- Identification of hub genes and compounds controlling ovarian cancer stem cell characteristics via stemness indices analysis. | Wang, Z., et al. 2021. Ann Transl Med. 9: 379. PMID: 33842600
- The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice. | Roques, BP., et al. 1980. Nature. 288: 286-8. PMID: 7001254
- Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzyme. | Battistini, B., et al. 1995. Br J Pharmacol. 114: 1383-90. PMID: 7606342
- Selective proteolitic activation and degradation of ETs and big ETs in parenchymal strips of the guinea-pig lung. | Battistini, B., et al. 1995. Biochem Biophys Res Commun. 207: 675-81. PMID: 7864859
- Bradykinin-induced contraction of guinea pig lung in vitro. | Lach, E., et al. 1994. Naunyn Schmiedebergs Arch Pharmacol. 350: 201-8. PMID: 7990978
- Neutral endopeptidase (EC 3.4.24.11) modulates the contractile effects of neuropeptides on muscle cells from the guinea-pig stomach. | Gu, ZF., et al. 1993. Exp Physiol. 78: 35-48. PMID: 8448012
- Distribution and abundance of neutral endopeptidase (EC 3.4.24.11) in the alimentary tract of the rat. | Bunnett, NW., et al. 1993. Am J Physiol. 264: G497-508. PMID: 8460703
- Inhibition of opioid-degrading enzymes potentiates delta9-tetrahydrocannabinol-induced antinociception in mice. | Reche, I., et al. 1998. Neuropharmacology. 37: 215-22. PMID: 9680246
- Enzymatic degradation of luteinizing hormone releasing hormone (LHRH)/[D-Ala6]-LHRH in lung pneumocytes. | Yang, X., et al. 1998. Pharm Res. 15: 1480-4. PMID: 9755904
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiorphan (DL), 5 mg | sc-201287 | 5 mg | $155.00 | |||
Thiorphan (DL), 25 mg | sc-201287A | 25 mg | $405.00 |