THAP1 Antibody (3H3): sc-135578
- THAP1 Antibody (3H3) is a mouse monoclonal IgG2b κ THAP1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant THAP1 protein of human origin
- recommended for detection of THAP1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for THAP1 Antibody (3H3). This work is in progress.
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THAP1 Antibody (3H3) is a mouse monoclonal IgG2b kappa light chain antibody that detects THAP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-THAP1 antibody (3H3) is available as a non-conjugated format. THAP1, or THAP domain containing, apoptosis associated protein 1, is a 213 amino acid protein primarily localized to the nucleoplasm and features a THAP-type zinc finger, which is a conserved DNA-binding domain crucial for function. THAP1 plays a significant role in regulating apoptosis, particularly through interaction with PAR4 protein, enhancing the likelihood of apoptosis induced by tumor necrosis factor and serum withdrawal. The pro-apoptotic nature of THAP1 is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to malignancies. THAP1 gene is located on human chromosome 8, a region associated with various diseases, including schizophrenia, bipolar disorder, and certain leukemias, highlighting THAP1′s importance in both normal cellular processes and disease states.
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THAP1 Antibody (3H3) References:
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. | Roussigne, M., et al. 2003. Trends Biochem Sci. 28: 66-9. PMID: 12575992
- THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. | Roussigne, M., et al. 2003. Oncogene. 22: 2432-42. PMID: 12717420
- The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. | Clouaire, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 6907-12. PMID: 15863623
- The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes. | Cayrol, C., et al. 2007. Blood. 109: 584-94. PMID: 17003378
- Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways. | Bessière, D., et al. 2008. J Biol Chem. 283: 4352-63. PMID: 18073205
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
THAP1 Antibody (3H3) | sc-135578 | 100 µg/ml | $339.00 |