Tyrosine Hydroxylase Antibody (6A477): sc-73151

TH Antibody (6A477) is a mouse monoclonal IgG1 antibody that detects tyrosine hydroxylase (TH) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TH is a critical enzyme that catalyzes the conversion of tyrosine to L-dopa, representing the rate-limiting step in the biosynthesis of catecholamines, including dopamine, adrenaline, and noradrenaline. TH (6A477) antibody is essential for studying normal levels of these neurotransmitters, which are vital for various physiological processes, including mood regulation, stress response, and motor control. Dysregulation of TH activity has been implicated in the pathogenesis of neurological disorders, particularly Parkinson′s disease, where reduced dopamine levels lead to significant motor and cognitive impairments. Additionally, the regulation of the TH gene is complex, involving transcription factor binding sites such as the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), which respond to various signaling pathways. Anti-TH antibody (6A477) provides reliable detection and analysis of TH, facilitating research into its role in health and disease.

The preferred Tyrosine Hydroxylase antibody is Tyrosine Hydroxylase Antibody (F-11): sc-25269.