TFII-I Antibody (42): sc-136099
- TFII-I Antibody (42) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 17-123 of TFII-I of human origin
- recommended for detection of TFII-I of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TFII-I Antibody (42). This work is in progress.
TFII-I Antibody (42) is a mouse monoclonal IgG1 antibody that detects TFII-I in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TFII-I is a crucial member of the transcription factor II (TFII) family, playing a significant role in the initiation of transcription for TATA-less promoters, which are essential for the expression of many genes, particularly in response to specific cellular signals. TFII-I is primarily located in the nucleus, where anti-TFII-I antibody (42) can detect interactions with RNA polymerase II and various basal transcription factors to form a transcription initiation complex. This localization is vital as TFII-I directly binds to core promoter elements, such as the pyrimidine-rich initiator and E-box sequences, facilitating the precise regulation of gene expression. Additionally, TFII-I is regulated by post-translational modifications, including tyrosine phosphorylation, which enhances transcriptional activity and is critical for the activation of downstream effector proteins like c-fos in the MAP kinase signaling pathway. TFII-I (42) monoclonal antibody enables researchers to gain insights into the mechanisms of gene regulation and the intricate signaling pathways that govern cellular responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFII-I Antibody (42) | sc-136099 | 50 µg/0.5 ml | $322.00 |