TFII-I Antibody (42): sc-136099
- TFII-I Antibody (42) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 17-123 of TFII-I of human origin
- recommended for detection of TFII-I of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TFII-I Antibody (42). This work is in progress.
TFII-I Antibody (42) is a mouse monoclonal IgG1 antibody that detects TFII-I in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TFII-I is a crucial member of the transcription factor II (TFII) family, playing a significant role in the initiation of transcription for TATA-less promoters, which are essential for the expression of many genes, particularly in response to specific cellular signals. TFII-I is primarily located in the nucleus, where anti-TFII-I antibody (42) can detect interactions with RNA polymerase II and various basal transcription factors to form a transcription initiation complex. This localization is vital as TFII-I directly binds to core promoter elements, such as the pyrimidine-rich initiator and E-box sequences, facilitating the precise regulation of gene expression. Additionally, TFII-I is regulated by post-translational modifications, including tyrosine phosphorylation, which enhances transcriptional activity and is critical for the activation of downstream effector proteins like c-fos in the MAP kinase signaling pathway. TFII-I (42) monoclonal antibody enables researchers to gain insights into the mechanisms of gene regulation and the intricate signaling pathways that govern cellular responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TFII-I Antibody (42) References:
- Biochemistry and biology of the inducible multifunctional transcription factor TFII-I. | Roy, AL. 2001. Gene. 274: 1-13. PMID: 11674993
- TFII-I and USF (RBF-2) regulate Ras/MAPK-responsive HIV-1 transcription in T cells. | Sadowski, I. and Mitchell, DA. 2005. Eur J Cancer. 41: 2528-36. PMID: 16223582
- TFII-I down-regulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor alpha. | Ogura, Y., et al. 2006. Genes Cells. 11: 373-81. PMID: 16611241
- Transcription factor TFII-I conducts a cytoplasmic orchestra. | Roy, AL. 2006. ACS Chem Biol. 1: 619-22. PMID: 17168565
- Signal-induced functions of the transcription factor TFII-I. | Roy, AL. 2007. Biochim Biophys Acta. 1769: 613-21. PMID: 17976384
- Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later. | Roy, AL. 2012. Gene. 492: 32-41. PMID: 22037610
- Epigenetic modulation by TFII-I during embryonic stem cell differentiation. | Bayarsaihan, D., et al. 2012. J Cell Biochem. 113: 3056-60. PMID: 22628223
- What role does TFII-I have to play in epigenetic modulation during embryogenesis? | Bayarsaihan, D. 2013. Epigenomics. 5: 9-11. PMID: 23414312
- Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci. | Shen, Y., et al. 2018. J Cell Biochem. 119: 712-722. PMID: 28657656
- Transcription factor TFII-I fine tunes innate properties of B lymphocytes. | Singh, A., et al. 2023. Front Immunol. 14: 1067459. PMID: 36756127
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFII-I Antibody (42) | sc-136099 | 50 µg/0.5 ml | $322.00 |