TFEC Antibody (E-12): sc-515031

TFEC Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects TFEC protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TFEC (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. TFEC protein plays a significant role in cellular processes, particularly in gene expression regulation and cellular differentiation. TFEC (E-12) monoclonal antibody recognizes a member of the basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor family, which is crucial for transcriptional regulation of various genes involved in development and cellular responses. TFEC protein is primarily expressed in fibroblasts, myoblasts, chondrosarcoma cells, and myeloma cells, distinguishing TFEC from closely related counterparts, TFE3 and MITF, which have broader expression patterns. This unique expression profile suggests TFEC′s potential involvement in specific cellular pathways and importance in understanding molecular mechanisms underlying certain diseases, including cancers. Anti-TFEC antibody (E-12) enables researchers to gain insights into TFEC′s functional roles and interactions within the cellular environment, ultimately contributing to a deeper understanding of biological significance.

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TFEC Antibody (E-12) References:

1. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.  |  Rehli, M., et al. 1999. Genomics. 56: 111-20. PMID: 10036191
2. TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.  |  Fisher, DE., et al. 1991. Genes Dev. 5: 2342-52. PMID: 1748288
3. Sequence-specific DNA binding by Myc proteins.  |  Kerkhoff, E., et al. 1991. Proc Natl Acad Sci U S A. 88: 4323-7. PMID: 1827916
4. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.  |  Beckmann, H., et al. 1990. Genes Dev. 4: 167-79. PMID: 2338243
5. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.  |  Puertollano, R., et al. 2018. EMBO J. 37: PMID: 29764979
6. TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling.  |  Zhao, T., et al. 2021. Exp Ther Med. 22: 1271. PMID: 34594408
7. MiT/TFE Family Renal Cell Carcinoma.  |  Tang, J. and Baba, M. 2023. Genes (Basel). 14: PMID: 36672892
8. Piebaldism and chromatophore development in reptiles are linked to the tfec gene.  |  Garcia-Elfring, A., et al. 2023. Curr Biol. 33: 755-763.e3. PMID: 36702128
9. The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction.  |  Artandi, SE., et al. 1994. Mol Cell Biol. 14: 7704-16. PMID: 7969114
10. Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator.  |  Yasumoto, K. and Shibahara, S. 1997. Biochim Biophys Acta. 1353: 23-31. PMID: 9256061
11. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.  |  Steingrímsson, E., et al. 1998. Development. 125: 4607-16. PMID: 9806910
12. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors.  |  Rehli, M., et al. 1999. J Immunol. 162: 1559-65. PMID: 9973413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TFEC Antibody (E-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TFEC Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TFEC Antibody (E-12) Specifications

Alternate Product Name: TFEC

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-68

Epitope Target: TFEC

Epitope Species: human

Product Reactivity/Detection: TFEC

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TFEC Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin