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Tenofovir Disoproxil Fumarate (CAS 202138-50-9)

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Alternate Names:
Viread
Application:
Tenofovir Disoproxil Fumarate is an acyclic phosphonate nucleotide analog and selective HIV-1 RT inhibitor
CAS Number:
202138-50-9
Purity:
≥98%
Molecular Weight:
635.51
Molecular Formula:
C19H30N5O10P•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tenofovir Disoproxil Fumarate is a compound studied in various research applications. In the field of materials science, its stability and solubility are often subjects of investigation, particularly in the development of novel formulation methods that could potentially improve the bioavailability of similar compounds. Research on Tenofovir Disoproxil Fumarate also involves its physicochemical properties and degradation pathways under different environmental conditions, which is essential for understanding its long-term storage and disposal implications. In analytical chemistry, the development of sensitive and selective detection methods for compounds like Tenofovir Disoproxil Fumarate is another area of focus, which can facilitate monitoring its presence and concentration in various matrices. Additionally, studies might explore the compound′s interaction with biological membranes to gain insights into passive diffusion mechanisms and molecular transport phenomena.


Tenofovir Disoproxil Fumarate (CAS 202138-50-9) References

  1. Is Tenofovir Alafenamide Safer than Tenofovir Disoproxil Fumarate for the Kidneys?  |  Aloy, B., et al. 2016. AIDS Rev. 18: 184-192. PMID: 27438578
  2. Tenofovir disoproxil fumarate induces pheochromocytoma cells apoptosis.  |  Lu, M., et al. 2019. Eur J Pharmacol. 844: 139-144. PMID: 30529468
  3. Switching tenofovir disoproxil fumarate to tenofovir alafenamide in a real life setting: what are the implications?  |  Schwarze-Zander, C., et al. 2020. HIV Med. 21: 378-385. PMID: 32065713
  4. Lamivudine/Tenofovir Disoproxil Fumarate is an Appropriate PrEP Regimen.  |  Mujugira, A., et al. 2020. Drugs. 80: 1881-1888. PMID: 33040323
  5. Tenofovir-disoproxil-fumarate modulates lipid metabolism via hepatic CD36/PPAR-alpha activation in hepatitis B virus infection.  |  Suzuki, K., et al. 2021. J Gastroenterol. 56: 168-180. PMID: 33211179
  6. Effect of tenofovir alafenamide vs. tenofovir disoproxil fumarate on hepatocellular carcinoma risk in chronic hepatitis B.  |  Lee, HW., et al. 2021. J Viral Hepat. 28: 1570-1578. PMID: 34435412
  7. Tenofovir disoproxil fumarate for multiple nucleos(t)ide analogues treatment failure hepatitis B: Is monotherapy enough?  |  Liang, X., et al. 2022. J Gastroenterol Hepatol. 37: 471-479. PMID: 34894002
  8. Point-of-care semi-quantitative test for adherence to tenofovir alafenamide or tenofovir disoproxil fumarate.  |  Sevenler, D., et al. 2022. J Antimicrob Chemother. 77: 996-999. PMID: 35038336
  9. Evaluation of tenofovir disoproxil fumarate loaded silver nanoparticle on testicular morphology in experimental type-2 diabetic rats.  |  Olojede, SO., et al. 2022. Artif Cells Nanomed Biotechnol. 50: 71-80. PMID: 35343349
  10. The role of tenofovir disoproxil fumarate for preventing vertical transmission of hepatitis B.  |  Pan, CQ. 2022. Antivir Ther. 27: 13596535221076640. PMID: 35499165
  11. Simplification from tenofovir disoproxil fumarate plus lamivudine or emtricitabine plus ritonavir-boosted protease inhibitor to ritonavir-boosted atazanavir plus lamivudine in virologically suppressed HIV-infected adults with osteopenia: a pilot study.  |  Blanco, JL., et al. 2022. J Antimicrob Chemother. 77: 1974-1979. PMID: 35512339
  12. Tenofovir disoproxil fumarate-mediated γ-globin induction is correlated with the suppression of trans-acting factors in CD34+ progenitor cells: A role in the reactivation of fetal hemoglobin.  |  Khan, F., et al. 2022. Eur J Pharmacol. 927: 175036. PMID: 35618038
  13. Switching from tenofovir alafenamide to tenofovir disoproxil fumarate improves lipid profile and protects from weight gain.  |  Kauppinen, KJ., et al. 2022. AIDS. 36: 1337-1344. PMID: 35727143

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tenofovir Disoproxil Fumarate, 10 mg

sc-208420
10 mg
$190.00

in which vehicle is it dissolved to administer it in a murine model?

Asked by: Patricia3
Thank you for your question. All of our products are exclusively designed and intended for in vitro research use. We do not have any data to support in vivo applications.
Answered by: Tech Support Europe
Date published: 2022-12-02

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2018-08-04
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Rated 5 out of 5 by from Tenofovir Disoproxil FumarateTenofovir Disoproxil Fumarate, was reported in many articles as an anitretroviral. -SCBT Publication Review
Date published: 2015-03-17
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Tenofovir Disoproxil Fumarate is rated 5.0 out of 5 by 1.
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