TEM8 Antibody (4H261): sc-73136

TEM8 Antibody (4H261) is a mouse monoclonal IgG1 kappa light chain antibody that detects TEM8 in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-TEM8 antibody (4H261) is available as a non-conjugated monoclonal isotype antibody. TEM8, also known as tumor endothelial marker 8, plays a crucial role in tumor angiogenesis, which is the formation of new blood vessels that supply nutrients to tumors, facilitating growth and metastasis. TEM8 is predominantly expressed in tumor endothelial cells, distinguishing them from normal endothelial cells, and elevated expression during tumor angiogenesis makes TEM8 a potential target for cancer therapies. TEM8 structure includes putative transmembrane domains, essential for functioning as a receptor for the protective antigen component of anthrax toxin. This interaction enables delivery of lethal factors into host cell cytosol, highlighting TEM8 significance in both cancer biology and infectious disease contexts. TEM8 unique expression pattern in tumors versus normal tissues underscores potential as a biomarker for cancer diagnosis and treatment strategies.

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TEM8 Antibody (4H261) References:

1. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.  |  Pellizzari, R., et al. 1999. FEBS Lett. 462: 199-204. PMID: 10580119
2. Genes expressed in human tumor endothelium.  |  St Croix, B., et al. 2000. Science. 289: 1197-202. PMID: 10947988
3. Cell surface tumor endothelial markers are conserved in mice and humans.  |  Carson-Walter, EB., et al. 2001. Cancer Res. 61: 6649-55. PMID: 11559528
4. Identification of the cellular receptor for anthrax toxin.  |  Bradley, KA., et al. 2001. Nature. 414: 225-9. PMID: 11700562
5. TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen.  |  Hotchkiss, KA., et al. 2005. Exp Cell Res. 305: 133-44. PMID: 15777794
6. Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.  |  Duan, HF., et al. 2007. J Natl Cancer Inst. 99: 1551-5. PMID: 17925540
7. Effect of silencing TEM8 gene on proliferation, apoptosis, migration and invasion of XWLC‑05 lung cancer cells.  |  Gong, Q., et al. 2018. Mol Med Rep. 17: 911-917. PMID: 29115620
8. Targeted silencing of TEM8 suppresses non‑small cell lung cancer tumor growth via the ERK/Bcl‑2 signaling pathway.  |  Gong, Q., et al. 2021. Mol Med Rep. 24: PMID: 34165155
9. N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.  |  Li, M., et al. 2021. Med Oncol. 38: 127. PMID: 34523032
10. Effects of anthrax toxin components on human neutrophils.  |  O'Brien, J., et al. 1985. Infect Immun. 47: 306-10. PMID: 3917427
11. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.  |  Leppla, SH. 1982. Proc Natl Acad Sci U S A. 79: 3162-6. PMID: 6285339
12. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.  |  Duesbery, NS., et al. 1998. Science. 280: 734-7. PMID: 9563949

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TEM8 Antibody (4H261) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TEM8 Antibody (4H261) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TEM8 Antibody (4H261) Specifications

Alternate Product Name: TEM8

Product Clone Name: 4H261

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 481-497

Epitope Target: TEM8

Epitope Species: human

Product Reactivity/Detection: TEM8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TEM8 Antibody (4H261): N/A