TEM8 Antibody (200C1339): sc-52959
- TEM8 Antibody (200C1339) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 481-497 of TEM8 of human origin
- recommended for detection of TEM8 of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TEM8 Antibody (200C1339). This work is in progress.
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TEM8 Antibody (200C1339) is a mouse monoclonal IgG1 antibody that detects TEM8 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). TEM8, also known as tumor endothelial marker 8, plays a crucial role in tumor angiogenesis, as TEM8 is highly expressed in tumor endothelial cells while remaining largely absent in normal endothelial cells. This differential expression highlights TEM8 as a potential target for cancer therapies aimed at disrupting blood supply to tumors. TEM8 is characterized by an N-terminal region, which encodes the anthrax toxin receptor (ATR), a type I membrane protein that facilitates anthrax toxin components′ entry into cells. The interaction between TEM8 and ATR helps understand how anthrax toxin evades the immune system, as ATR binds the protective antigen component, allowing delivery of lethal factors into the cytosol. The first 364 amino acids of ATR are identical to TEM8, indicating a close relationship, although C-terminal regions differ due to alternative splicing. This structural distinction may influence functional roles in tumor biology and toxin susceptibility, making TEM8 significant for cancer and infectious disease research.
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TEM8 Antibody (200C1339) References:
- TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. | Byrd, TT., et al. 2018. Cancer Res. 78: 489-500. PMID: 29183891
- TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation. | Zhang, LC., et al. 2018. Cell Commun Signal. 16: 62. PMID: 30241478
- Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth. | Evans, DJ., et al. 2018. Front Oncol. 8: 506. PMID: 30460197
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo. | Petrovic, K., et al. 2019. PLoS One. 14: e0224015. PMID: 31622431
- The relationship between TEM8 and early diagnosis and prognosis of lung cancer. | Sun, M., et al. 2021. Minerva Med. 112: 359-364. PMID: 32166929
- Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways. | Wang, CX., et al. 2020. Am J Transl Res. 12: 3557-3576. PMID: 32774719
- TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer. | Xu, J., et al. 2021. Nat Commun. 12: 4413. PMID: 34285210
- Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics. | Corbett, V., et al. 2022. Front Mol Biosci. 9: 930207. PMID: 36090051
- TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity. | Kaminski, MF., et al. 2022. J Immunother Cancer. 10: PMID: 36162918
- DNA Methylation in Recurrent Glioblastomas: Increased TEM8 Expression Activates the Src/PI3K/AKT/GSK-3β/B-Catenin Pathway. | Kundu, P., et al. 2024. Cancer Genomics Proteomics. 21: 485-501. PMID: 39191501
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TEM8 Antibody (200C1339) | sc-52959 | 100 µg/ml | $339.00 |