TCR V β 11 Antibody (3H2943): sc-73125

TCR V β 11 Antibody (3H2943) is a rat monoclonal IgG2b antibody that detects TCR V beta 11 of mouse origin by flow cytometry (FCM). Anti-TCR V beta 11 antibody (3H2943) is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling that activates T cells, transitioning them from a dormant to an active state. The TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with approximately 95% of circulating T cells expressing the alpha/beta heterodimer. This diversity in TCR specificity is essential for the immune system to recognize a wide array of antigens, achieved through the somatic recombination of variable (V), diversity (D), and joining (J) gene segments during T cell development. The TCR beta and gamma chain genes are located in distinct loci, while the genes for the TCR alpha and delta chains are found within a single locus. Notably, the synthesis of the beta chain involves a complex process of joining D and J segments, followed by the addition of a V segment, and ultimately a constant (C) segment. Understanding the structure and function of the TCR is vital, as genetic mutations in the T cell receptor beta locus have been linked to T cell lymphomas, highlighting the importance of TCR V beta 11 in both normal immune function and disease.

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TCR V β 11 Antibody (3H2943) References:

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10. T cell vaccination against autoimmune diabetes in nonobese diabetic mice.  |  Formby, B. and Shao, T. 1993. Ann Clin Lab Sci. 23: 137-47. PMID: 8096128
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12. Immune response during tumor therapy with antibody-superantigen fusion proteins.  |  Rosendahl, A., et al. 1996. Int J Cancer. 68: 109-13. PMID: 8895549

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.