TCR C β 1 Antibody (JOVI.1): sc-53196
- TCR C β 1 Antibody (JOVI.1) is a mouse monoclonal IgG2a κ TCR C β 1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR
- TCR C beta 1 Antibody (JOVI.1) is recommended for detection of TCR C β 1 of human origin by WB, IP, IF and FCM
- TCR C beta 1 Antibody (JOVI.1) is available conjugated to agarose for IP; to HRP for WB, IHC(P) and ELISA; and to FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TCR C β 1 Antibody (JOVI.1) for WB applications. These reagents are now offered in bundles with TCR C β 1 Antibody (JOVI.1) (see ordering information below).
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TCR C β 1 Antibody (JOVI.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects the TCR C beta 1 protein of human origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TCR C β 1 (JOVI.1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling that activates T cells, transitioning them from a dormant to an active state. TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with approximately 95% of circulating T cells expressing the alpha/beta heterodimer. The diversity of the TCR repertoire is essential for recognizing a wide array of antigens, achieved through somatic recombination of variable (V), diversity (D), joining (J), and constant (C) gene segments during T cell development. The TCR beta and gamma chain genes are located in distinct loci, while the genes for the TCR alpha and delta chains are found within a single locus. Notably, the beta chain is synthesized by first joining a D segment with a J segment, followed by the addition of a V segment, with the C segment being joined later through RNA splicing. Genetic mutations in the T cell receptor beta locus have been linked to T cell lymphomas, highlighting the importance of TCR integrity in immune function and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCR C β 1 Antibody (JOVI.1) References:
- The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. | Hernández, J., et al. 2000. J Immunol. 164: 596-602. PMID: 10623800
- Signal transduction by the TCR for antigen. | Kane, LP., et al. 2000. Curr Opin Immunol. 12: 242-9. PMID: 10781399
- Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice. | Viney, JL., et al. 1992. Hybridoma. 11: 701-13. PMID: 1284120
- Characterization of a rat monoclonal antibody specific for a determinant encoded by the V beta 7 gene segment. Depletion of V beta 7+ T cells in mice with Mls-1a haplotype. | Okada, CY., et al. 1990. J Immunol. 144: 3473-7. PMID: 1691759
- Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions. | Sugihara, S., et al. 1993. J Immunol. 150: 683-94. PMID: 7678281
- Identification of two V beta 7-specific viral superantigens. | Ignatowicz, L., et al. 1994. J Immunol. 152: 65-71. PMID: 8254207
- Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex. | Bowness, P., et al. 1998. Eur J Immunol. 28: 2704-13. PMID: 9754558
- TCR usage in human and experimental demyelinating disease. | Hafler, DA., et al. 1996. Immunol Today. 17: 152-9. PMID: 8871344
- Thymocyte selection: not by TCR alone. | Amsen, D. and Kruisbeek, AM. 1998. Immunol Rev. 165: 209-29. PMID: 9850863
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR C β 1 Antibody (JOVI.1) | sc-53196 | 200 µg/ml | $322.00 | |||
TCR C β 1 Antibody (JOVI.1): m-IgG Fc BP-HRP Bundle | sc-525582 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCR C β 1 Antibody (JOVI.1): m-IgG2a BP-HRP Bundle | sc-546325 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCR C β 1 Antibody (JOVI.1) AC | sc-53196 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TCR C β 1 Antibody (JOVI.1) HRP | sc-53196 HRP | 200 µg/ml | $322.00 | |||
TCR C β 1 Antibody (JOVI.1) FITC | sc-53196 FITC | 200 µg/ml | $336.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 488 | sc-53196 AF488 | 200 µg/ml | $364.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 546 | sc-53196 AF546 | 200 µg/ml | $364.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 594 | sc-53196 AF594 | 200 µg/ml | $364.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 647 | sc-53196 AF647 | 200 µg/ml | $364.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 680 | sc-53196 AF680 | 200 µg/ml | $364.00 | |||
TCR C β 1 Antibody (JOVI.1) Alexa Fluor® 790 | sc-53196 AF790 | 200 µg/ml | $364.00 |