Anti-TCR Antibody (H57-597)recommended for detection of a common epitope of the β chain of the T-cell Receptor (TCR) complex on α/β TCR expressing T lymphocytes and thymocytes of mouse origin by IP, IF and FCM
TCR Antibody (H57-597) is a Armenian hamster monoclonal IgG, cited in 4 publications, provided at 200 µg/ml
raised against affinity purified murine T cell receptor
recommended for detection of a common epitope of the β chain of the T-cell Receptor (TCR) complex on α/β TCR expressing T lymphocytes and thymocytes of mouse origin by IP, IF and FCM; non cross-reactive with gd TCR-bearing T cells
available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
also provided azide-free for stimulation of T cells, sc-18904 L, 200 µg/0.1 ml
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCR Antibody (H57-597). This work is in progress.
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The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. TCR is a heterodimer composed of either α and β or γ and δ chains. The vast majority of circulating T cells (95%) express the α/β heterodimer while roughly 2-5% express the γ/δ heterodimer. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD4 is also expressed on cortical cells, mature medullary thymocytes, microglial cells and dendritic cells. CD4, also designated T4 and Leu 3, is a membrane glycoprotein that contains four extracellular immunoglobin-like domains. The TCR, in association with CD4, can bind class II MHC molecules presented by the antigen-presenting cells. The CD4 protein functions by increasing the avidity of the interaction between the TCR and an antigen-class II MHC complex.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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